PMID: 6539617Jun 1, 1984Paper

Bilateral cutaneous stimulation of the somatosensory system in hemidecorticate rats

Behavioral Neuroscience
T Schallert, I Q Whishaw

Abstract

An enduring somatosensory consequence of extensive neocortex injury in people is "simultaneous extinction," which is an interhemispheric perceptual interaction that is operationally distinguishable from neglect. A cutaneous stimulus presented on the contralateral side of the body is readily detected when presented singly but is actively masked during bilateral stimulation. In hemidecorticate rats, small adhesive stimuli were attached to the radial surface of each forelimb simultaneously, and the latencies to contact and to remove each stimulus were recorded. Neglect of the contralateral stimulus lasted 2-3 days. Thereafter the ipsilateral stimulus was removed first, followed immediately by the contralateral stimulus. This ipsilateral sensorimotor bias lasted several months. Further analysis with unremovable tactile stimuli provided evidence for true extinction. For a limited period (during the first 2 postoperative weeks), the contralateral stimulus did not appear to be detected in the presence of the ipsilateral stimulus. Rather than switching back and forth between the two stimuli, the animals ignored the stimulus on the contralateral limb and persisted in their attempts to remove the ipsilateral stimulus. A key feature of th...Continue Reading

Citations

Oct 3, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Timothy Schallert
Jun 15, 2006·Nutrition Reviews·Betsy LozoffTimothy Schallert
Dec 6, 2008·Stroke; a Journal of Cerebral Circulation·Yaoming WangBerislav V Zlokovic
Feb 10, 2010·Experimental & Translational Stroke Medicine·J Michael GeeKyra J Becker
Mar 8, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dustin J Hines, Philip G Haydon

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