Abstract
Ventriculostomy-associated cerebrospinal fluid infection (VAI) is a major complication limiting the use of an external ventricular drain (EVD) in treating patients with intraventricular hemorrhage (IVH). Risk factors of VAI are still under wide discussion. We performed a retrospective review of 84 patients with IVH who underwent EVD at our center between January 2012 and January 2017. Preoperative clinical parameters, surgeon status, number of catheters and catheter-days, subgaleal tunneling distance, frequency of urokinase flush, and prophylactic antibiotics were compared between the infective and noninfective groups. The overall rate of VAI was 31.0%. Univariate analysis showed a higher modified Graeb Score (mGS), higher proportion of bilateral catheters, and longer hospital stay in patients with VAI. Binary logistic analysis of all clinical factors identified high mGS (≥16) as an independent risk factor for VAI (odds ratio, 3.242; P = 0.026). Among operative and postoperative factors, the use of bilateral catheters significantly contributed to VAI (odds ratio, 4.211; P = 0.031), but a subgroup comparison showed an increased VAI rate only in the low mGS group (mGS <15). No VAI occurred in patients with a single EVD in the low...Continue Reading
References
Nov 4, 2000·Neurosurgery·C H AlleyneJ M Zabramski
Feb 24, 2001·Acta neurochirurgica·F LundbergA Ljungh
Jun 18, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·W PfistererA Reinprecht
Sep 1, 2004·Neurosurgery·Paul ParkB Gregory Thompson
Feb 2, 2013·Stroke; a Journal of Cerebral Circulation·Timothy C MorganUNKNOWN CLEAR and VISTA Investigators
Jan 9, 2015·BMC Infectious Diseases·Mahesh RamananAparna Shankar
Jan 31, 2015·Neurosurgery·Mahua DeyUNKNOWN CLEAR III Trial Investigators
Oct 21, 2016·The Journal of Hospital Infection·H HumphreysUNKNOWN Healthcare Infection Society Working Party on Neurosurgical Infections
Jan 24, 2017·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Rachel WeinsteinShawna Cutting
Jun 7, 2017·Neurosurgery·Justin A Neira, Guy M McKhann
Sep 10, 2017·Neurology·Maged D FamUNKNOWN CLEAR III Trial Investigators
Oct 11, 2017·World Neurosurgery·Jaechan ParkHyun-Ha Chang
Oct 27, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Aimun A B JamjoomUNKNOWN British Neurosurgical Trainee Research Collaborative
Dec 2, 2017·World Neurosurgery·Wang KaiZhao Guoguang
Citations
Nov 25, 2018·Acta neurochirurgica·Sofia Kamakh Asaad, Carsten Reidies Bjarkam
Jan 30, 2020·Expert Review of Anti-infective Therapy·Kirsten R I S DorresteijnDiederik van de Beek
May 1, 2020·Surgical Infections·Yuanrun ZhuXiaofeng Yang
Feb 25, 2020·The Journal of Infection·Kirsten R I S DorresteijnKorné Jellema