Bilateral hippocampal volume predicts verbal memory function in temporal lobe epilepsy

Epilepsy & Behavior : E&B
Sheryl L RemingerKris L Kaemingk

Abstract

The present study used quantitative volume estimates of the hippocampus based on structural magnetic resonance imaging (MRI) to predict memory performance of individuals with epilepsy of temporal lobe origin (TLE). Twenty individuals with TLE completed standardized neuropsychological tests and a quality of life inventory, and participated in a brain MRI protocol designed to obtain high-resolution images of the hippocampus. The combined volume of the left and right hippocampi was found to be the best predictor of objective verbal memory performance. This finding is consistent with the functional adequacy model of hippocampal function. In contrast, the asymmetry between right and left hippocampal volume was the best predictor of subjective ratings of cognitive functioning, which is consistent with the functional reserve model. The collective and complementary functions of the left and right hippocampi merit further exploration in prospective studies of memory function and TLE.

References

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Citations

Feb 17, 2007·Epilepsy Currents·Cynthia L Harden
Feb 11, 2009·Journal of the International Neuropsychological Society : JINS·Robert J ThomaJose M Cañive
Sep 16, 2008·Brain : a Journal of Neurology·Yifat Glikmann-JohnstonDavid C Reutens
Dec 17, 2008·Brain : a Journal of Neurology·C R ButlerA Z Zeman
Mar 15, 2008·Clinical Neurology and Neurosurgery·Marielle C G VlooswijkAlbert P Aldenkamp
Mar 21, 2007·Epilepsy & Behavior : E&B·Bernd WeberChristian E Elger
Apr 17, 2008·The European Journal of Neuroscience·Luke C HenryG Campbell Teskey
Jul 22, 2014·Seizure : the Journal of the British Epilepsy Association·Virginie VoltzenlogelLiliann Manning
Dec 7, 2010·Epilepsy & Behavior : E&B·Sallie Baxendale, Dominic Heaney

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