Bilateral injection-site granuloma by subcutaneous administration of luteinizing hormone-releasing hormone analogue: a case report.

Cases Journal
Riko KitazawaSohei Kitazawa

Abstract

We report a typical case of injection-site granuloma attributed to subcutaneous administration of leuprorelin acetate, an LHRH agonist. A 70-year-old man who had undergone total prostatectomy and was subsequently given leuprorelin injections for prostatic cancer presented with bilateral nodules in the lower abdominal wall. An excisional biopsy revealed a non-caseous epithelioid granuloma consisting of CD-68 positive histiocytic cells with infiltration of T-lymphocytes and eosinophils; skin metastasis from prostatic adenocarcinoma was ruled out through histological and immunohistochemical analysis. Generally, granulomas may be caused by delayed-type hypersensitivity to the constituents of leuprorelin acetate injections.

References

Oct 1, 1984·Archives of Dermatology·H A Fawcett, N P Smith
Aug 1, 1993·The Journal of Pediatrics·P K ManascoR M Blizzard
Feb 14, 2006·The Journal of Dermatology·Ryoko SakamotoTamotsu Kanzaki
Sep 20, 2007·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Masaki ShiotaHumio Yamasaki

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Citations

Jul 10, 2019·International Journal of Dermatology·Xavier GrimauxAnne Croue

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