Bilateral innervation of the cerebral arteries by the superior cervical ganglion in cats

Journal of Neurosurgery
J MarinE J Marco

Abstract

The effect of removal of the left superior cervical ganglion on the contractile response to norepinephrine (NE) and 5-hydroxytryptamine (5-HT, serotonin) was studied in isolated segments of the middle cerebral artery (MCA) and posterior communicating artery (PCoA) of the cat. Fifteen days after the excision, each dose of NE elicited a potentiated response in both the MCA and the PCoA, whichever side they originated. By contrast, 5-HT induced enhanced vasoconstriction at each dose only in the MCA and PCoA from the left side. When segments of MCA and PCoA from the right side were challenged against 5-HT, a significantly increased response was found only at the first three doses. On the other hand, the NE content of pools made of MCA, PCoA, and anterior cerebral artery from each side was reduced to the same level on both sides after ganglion removal. These results indicate that the excised superior cervical ganglion innervated the MCA and PCoA from both sides of the circle of Willis.

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Citations

Jan 1, 1982·Histochemistry·H HaraS Tsukahara
Jul 8, 1985·Brain Research·E J MarcoJ Marín
Jan 1, 1982·General Pharmacology·J Marín, F Rivilla
Jan 1, 1983·General Pharmacology·M SalaícesS Lluch
Jan 1, 1990·General Pharmacology·M T BarrúsJ Marín
Aug 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D DuvergerB Zivkovic
Feb 1, 1995·Stroke; a Journal of Cerebral Circulation·M J MorenoE J Marco
Nov 1, 1983·Journal of Neurochemistry·M HadjiconstantinouN H Neff
Jun 1, 1983·Journal of Neurosurgery·T Yamashima, S Yamamoto
Nov 1, 1992·Journal of Neurosurgery·R M PlutaE H Oldfield
Nov 1, 1985·Journal of Neurosurgery·M D ShawD W Chadwick
Sep 1, 1984·Journal of Neurosurgery·T TakemaeJ F Alksne
Dec 1, 1985·Journal of Neurosurgery·E AlexanderN T Zervas
Apr 1, 1990·Journal of Neurosurgery·M R MaybergD H Bark
Jun 1, 1990·Journal of Neurosurgery·C A GillerH H Batjer
Apr 1, 1985·Journal of Neurosurgery·J P KappR R Smith
Nov 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A JackowskiF Kristek
Oct 1, 1992·The Journal of Pharmacy and Pharmacology·M T BarrúsG Balfagón

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Methods Mentioned

BETA
fluorescence microscopy
PCA

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