Bilateral internuclear ophthalmoplegia after intrathecal chemotherapy and cranial irradiation

American Journal of Ophthalmology
F E Lepore, M J Nissenblatt

Abstract

A 26-year-old man developed transient bilateral internuclear ophthalmoplegia with exotropia after cranial irradiation and intrathecal administration of methotrexate for lymphoma. Resolution of the ophthalmoplegia and the decrease in abnormally high levels of cerebrospinal fluid myelin basic protein after discontinuation of intrathecal medication suggested demyelination from chemotherapy and irradiation.

References

Oct 1, 1979·Neurology·D E Wilkins, A M Samhouri
Apr 1, 1978·Southern Medical Journal·A N KrutchikA U Buzdar
Jul 1, 1974·Archives of Ophthalmology·J R RichR S Hepler
Nov 1, 1970·Archives of Ophthalmology·D G Cogan
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Mar 1, 1960·Archives of Neurology·N CHRISTOFFM B BENDER

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Citations

Nov 1, 1989·Survey of Ophthalmology·P S ImperiaJ H Lass
Mar 11, 2020·BMJ Open Ophthalmology·Clara M Castillejo BecerraAlexa Simon Meara
May 25, 2016·Cancer Control : Journal of the Moffitt Cancer Center·Lynn E Harman

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