PMID: 12766653May 27, 2003Paper

Bilateral intravenous regional anesthesia: a new method to test additives to local anesthetic solutions

Anesthesiology
M W HartmannsgruberP G Atanassoff

Abstract

Ketorolac, when added to lidocaine, has been shown to reduce early tourniquet pain during intravenous regional anesthesia (i.v.RA) in patients. Although the effectiveness of ropivacaine 0.2% for i.v.RA is equal to that of lidocaine 0.5% but significantly reduces central nervous system side effects after release of the tourniquet, it provides no advantage with regard to tourniquet tolerance times. Simultaneous bilateral i.v.RA with ropivacaine 0.2% was used to test the hypothesis that ketorolac modifies tourniquet tolerance and to test whether drug combinations can be evaluated in one study session. Ten healthy, unsedated volunteers received 30 ml of ropivacaine 0.2% in each upper arm with 2 ml of normal saline in one arm and 30 mg of ketorolac in the contralateral arm for i.v.RA. Both proximal tourniquets remained inflated for 30 min, followed by inflation of the distal tourniquets and release of the proximal ones. Verbal numeric scores for tourniquet pain were recorded for both extremities. Central nervous system side effects were graded after release of each distal tourniquet. There was no difference between the two upper extremities with regard to surgical anesthesia and tourniquet tolerance. Total tourniquet tolerance was a...Continue Reading

References

Oct 2, 1982·British Medical Journal·M L Heath
Jul 1, 1995·Anesthesia and Analgesia·S S ReubenK M Duprat
Nov 1, 1993·Anesthesiology·S Petersen-FelixD A Thomson
Nov 14, 1997·Anesthesia and Analgesia·B Korman, R H Riley
Oct 15, 1998·British Journal of Anaesthesia·E I AbouleishC Nelson
Sep 4, 1999·Anesthesia and Analgesia·M W HartmannsgruberP G Atanassoff
Jan 10, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Andrew Choyce, Philip Peng

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Citations

Jun 23, 2011·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Marie-Hélène TremblayHimat Vaghadia
Nov 16, 2010·Anesthesiology Clinics·Usha RamadhyaniBobby D Nossaman

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