Bilateral lesions of the subthalamic nucleus induce multiple deficits in an attentional task in rats

The European Journal of Neuroscience
Christelle Baunez, T W Robbins

Abstract

Lesioning the subthalamic nucleus (STN) has been suggested as possible therapy for the treatment of parkinsonism. Previous experiments investigating this hypothesis in rats confirmed that excitotoxic STN lesions alleviate the motor impairment induced by striatal dopamine depletion, which reproduced the degeneration observed in parkinsonism, but elicited presumed non-motor deficits such as premature responding, suggesting that the STN could be involved in other aspects of response control. The aim of the present study was to extend this analysis to choice paradigms. We thus investigated the behavioural effects of bilateral excitotoxic lesions of the STN in rats performing a five-choice test of divided and sustained visual attention, modelled on the human continuous performance task. This task required the animals to detect a brief visual stimulus presented in one of five possible locations and respond by a nose-poke in this illuminated hole within a fixed delay, for food reinforcement. Bilateral lesions of the STN severely impaired several aspects of performance, including discriminative accuracy, but also increased premature, anticipatory responding as well as perseverative panel pushes and nose-poke responses. While increasing...Continue Reading

References

Jul 1, 1990·Trends in Neurosciences·M R DeLong
Jan 1, 1991·Movement Disorders : Official Journal of the Movement Disorder Society·T Z AzizA R Crossman
Apr 22, 1990·The Journal of Comparative Neurology·H J Groenewegen, H W Berendse
Jun 1, 1985·The Journal of Comparative Neurology·S Afsharpour
Oct 1, 1989·Trends in Neurosciences·R L AlbinJ B Penney
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
May 1, 1983·Behavioural Brain Research·E Kafetzopoulos, G Papadopoulos
Aug 1, 1994·Journal of Neurophysiology·T WichmannM R DeLong
Aug 1, 1994·Journal of Neurophysiology·H BergmanM R DeLong
May 1, 1993·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M AmalricG F Koob

❮ Previous
Next ❯

Citations

May 14, 2009·Psychopharmacology·Tommy PattijAnton N M Schoffelmeer
Dec 31, 2010·Journal of Neural Transmission·M BočkováI Rektor
Feb 26, 2013·Behavioural Brain Research·Lily R AleksandrovaJosé N Nobrega
Mar 23, 2013·Behavioural Brain Research·Annamaria CapozzoEugenio Scarnati
Jun 12, 2013·Behavioural Brain Research·Jean-Michel ReymannDanièle Bentué-Ferrer
Jun 4, 2005·Physiology & Behavior·Craig J Slawecki, Jennifer Roth
Jul 20, 2002·Progress in Neurobiology·André Nieoullon
Aug 4, 2010·Nature Reviews. Neurology·Jens VolkmannKarsten Witt
Apr 27, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sylvie Lardeux, Christelle Baunez
Dec 7, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jason M UslanerTerry E Robinson
Aug 24, 1999·The European Journal of Neuroscience·J M HendersonS B Dunnett
Sep 22, 2010·Brain : a Journal of Neurology·Tamara HersheyJoel S Perlmutter
Nov 10, 2010·Brain : a Journal of Neurology·Maria C Rodriguez-OrozJose A Obeso
Feb 1, 2013·Brain : a Journal of Neurology·Pierre BurbaudUNKNOWN French Stimulation dans le Trouble Obsessionnel Compulsif Study Group
Apr 13, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael J FrankScott J Sherman
Sep 13, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Baltazar ZavalaPeter Brown
May 23, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Baltazar A ZavalaPeter Brown
Dec 18, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·P KrackP Pollak
Oct 27, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Anne BuotLuc Mallet
May 14, 2014·Proceedings of the National Academy of Sciences of the United States of America·Nadine SchweizerÅsa Wallén-Mackenzie
Nov 8, 2005·Experimental Brain Research·Yasin TemelVeerle Visser-Vandewalle
Jun 15, 2005·Archives of Physical Medicine and Rehabilitation·Victor W MarkAdam J Woods
Feb 12, 2011·Acta neurochirurgica·Won Seok ChangJin Woo Chang
Sep 24, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Carine KarachiChantal François

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Atypical Parkinsonism (MDS)

Atypical Parkinsonism presents with the same signs and symptoms of Parkinson's disease, but do not respond to typical Parkionson's disease treatment with levodopa. Atypical Parkinsonism is thought to be associated with abnormal protein buildup within brain cells. Here is the latest on Atypical Parkinsonism.

Basal ganglia in Parkinson's disease (MDS)

The basal ganglia is comprised of the neostriatum, the external and internal pallidal segments, the subthalamic nucleus, the substantia nigra pars reticulata, and the pars compacta of the substantia nigra. The basal ganglia circuitry is responsible for the correct execution of voluntary movements and is implicated in Parkinson's disease. Here is the latest research investigating the basal ganglia in Parkinson's disease.