Bilateral Leydig cell tumor in a six-year-old intersex goat affected by Polled Intersex Syndrome

Veterinary Pathology
L V MonteagudoI Sierra

Abstract

A 6-year-old, sterile, Blanca Celtibérica breed adult doe was referred to our faculty. The doe had external female genitalia, a short anogenital distance, and normally shaped udders. Masculinization signs in the head shape and male behavior were also noted at the time of referral. Genetic analysis demonstrated normal 2n = 60 XX karyotype and an absence of the sex-determining region Y (SRY). The animal was homozygous for a DNA deletion responsible for the Polled Intersex Syndrome (PIS). A uterus and 2 uterine horns were present at the postmortem examination. Gartner's ducts and degenerated Wolffian derivatives persisted. There were 2 intra-abdominal testicle-like structures, one of which consisted of epididymal and deferent ducts. An advanced Leydig cell tumor, resulting in almost total destruction of the intratesticular structures, was also observed. Leydig cell tumors usually produce testosterone. Thus, these histologic findings are compatible with the evident virilization.

References

Dec 1, 2001·Nature Genetics·E PailhouxD Vaiman

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Citations

Jun 8, 2011·The Journal of Veterinary Medical Science·Shinichi YokotaYoshiaki Hikasa
Jun 6, 2008·Animal Reproduction Science·G PajaresL J Royo
Sep 16, 2014·Reproduction in Domestic Animals = Zuchthygiene·I F CanissoR O Gilbert
Dec 29, 2020·The Veterinary Clinics of North America. Food Animal Practice·Jamie L Stewart, Clifford F Shipley

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Methods Mentioned

BETA
PCR
electrophoresis

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