Bilateral lipomastia in men: a side effect of highly active antiretroviral therapy

International Journal of Surgical Pathology
Julian DeonarainBhugwan Singh

Abstract

Breast enlargement in men and women is a documented feature of the highly active antiretroviral therapy- associated human immunodeficiency virus lipodystrophy syndrome. The exact underlying histomorphological features of this condition are speculative because most cases are diagnosed on clinical grounds with or without radiographic confirmation. The main documented causes of breast enlargement in men on highly active antiretroviral therapy include gynecomastia and lipomastia; however, biopsy-confirmed lipomastia is a rarely described phenomenon, with only 1 such case being described to date. In documenting 2 patients who underwent bilateral mastectomy for clinical gynecomastia of unknown cause, we emphasize the need for a greater degree of clinicopathological awareness of highly active antiretroviral therapy-associated lipomastia and the role of the histopathologist in the informed management of patients afflicted with human immunodeficiency virus infection on highly active antiretroviral therapy.

References

Oct 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M Hartstein, H L Leaf
Feb 18, 1993·The New England Journal of Medicine·G D Braunstein
Nov 14, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·I HerryC Perronne
Jun 27, 1998·Lancet·P Arner
Aug 26, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F MontiT Desiderio
Sep 6, 2002·Clinical Imaging·Vincenzo SchininàCorrado Bibbolino
Oct 18, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Devon L EvansDavid M Aboulafia
Jun 24, 2003·AJR. American Journal of Roentgenology·James M BuschPhyllis J Kornguth
May 6, 2004·The Breast Journal·Francisco JoverJaime Merino
Dec 22, 2004·Journal of Surgical Oncology·Soji F OluwoleHector A DePaz

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Citations

Jan 17, 2012·Polski przeglad chirurgiczny·Anna Kasielska, Bogusław Antoszewski
Oct 2, 2012·The Australasian Medical Journal·Smita Sankaye, Sushil Kachewar
Jun 7, 2011·The Breast : Official Journal of the European Society of Mastology·Liron PantanowitzDaniel Skiest
Nov 21, 2017·PloS One·Victor SinganoJoep J van Oosterhout

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