Bilateral low frequency rTMS of the primary motor cortex may not be a suitable treatment for levodopa-induced dyskinesias in late stage Parkinson's disease

Parkinsonism & Related Disorders
Anja FlamezChris Baeken

Abstract

In late stage Parkinson patients there is an unmet need for new treatments to adequately control motor complications, especially dyskinesias. In several preliminary studies, it has been suggested that applying unilateral low-frequency repetitive transcranial magnetic stimulation (LF rTMS), delivered at the primary motor cortex (MC) or the supplementary motor area (SMA), may reduce levodopa-induced dyskinesias (LID), either in a single or a multiple session stimulation protocol. In our current clinical research, we examined whether single or multiple (accelerated) sham-controlled bilateral LF rTMS session(s) applied to the primary motor cortices are able to reduce levodopa-induced dyskinesias in patients with advanced Parkinson's disease. During a levodopa challenge test, we first investigated the effect of a single sham-controlled session of LF rTMS (1 Hz) to both left and right primary motor cortical areas on dyskinesias and motor function in nine late-stage Parkinson patients. In a second study, patients were assigned to a five day sham-controlled bilateral motor cortex cross-over accelerated LF rTMS protocol and effects on dyskinesias, motor and executive function and emotional status were assessed. We found no significant c...Continue Reading

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Citations

Jan 26, 2017·Neuroscience and Biobehavioral Reviews·Lars DinkelbachAnna-Katharine Brem
Aug 18, 2018·The European Journal of Neuroscience·Francesco TurcoIoannis U Isaias
Feb 18, 2020·Journal of Parkinson's Disease·Lívia ShirahigeKátia Monte-Silva
Jan 7, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jean-Pascal LefaucheurUlf Ziemann
Feb 27, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Anja FlamezChris Baeken
Feb 27, 2021·Molecular Medicine·Theodora NtetsikaIoanna Markaki
Mar 21, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Penghui SongYuping Wang

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