Bilateral mammographic density asymmetry and breast cancer risk: a preliminary assessment.

European Journal of Radiology
Bin ZhengDavid Gur

Abstract

To improve efficacy of breast cancer screening and prevention programs, it requires a risk assessment model with high discriminatory power. This study aimed to assess classification performance of using computed bilateral mammographic density asymmetry to predict risk of individual women developing breast cancer in near-term. The database includes 451 cases with multiple screening mammography examinations. The first (baseline) examinations of all case were interpreted negative. In the next sequential examinations, 187 cases developed cancer or surgically excised high-risk lesions, 155 remained negative (not-recalled), and 109 were recalled benign cases. From each of two bilateral cranio-caudal view images acquired from the baseline examination, we computed two features of average pixel value and local pixel value fluctuation. We then computed mean and difference of each feature computed from two images. When applying the computed features and other two risk factors (woman's age and subjectively rated mammographic density) to predict risk of cancer development, areas under receiver operating characteristic curves (AUC) were computed to evaluate the discriminatory/classification performance. The AUCs are 0.633±0.030, 0.535±0.036,...Continue Reading

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Citations

Apr 15, 2014·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Wenqing SunWei Qian
Dec 4, 2014·Breast Cancer Research : BCR·Anthony HowellMichelle N Harvie
Nov 2, 2014·IEEE Transactions on Medical Imaging·Paola CastiRangaraj M Rangayyan
Apr 16, 2016·Journal of Magnetic Resonance Imaging : JMRI·Faranak AghaeiBin Zheng
Aug 5, 2015·BioMed Research International·José Celaya-PadillaJosé Tamez-Peña
Aug 31, 2016·Proceedings of the National Academy of Sciences of the United States of America·Karla K EvansJeremy M Wolfe
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Apr 19, 2018·Physics in Medicine and Biology·Seyedehnafiseh MirniaharikandeheiBin Zheng
May 19, 2017·Physics in Medicine and Biology·Rebekah H GriesenauerMichael I Miga
Oct 30, 2019·The British Journal of Radiology·Sue M HudsonIsabel Dos-Santos-Silva
May 20, 2015·Physics in Medicine and Biology·Maxine TanBin Zheng
Jan 1, 2019·Visual Computing for Industry, Biomedicine and Art·Bin ZhengGopichandh Danala
Jul 21, 2017·International Journal of Computer Assisted Radiology and Surgery·Shiju YanBin Zheng
Oct 20, 2020·Patterns·Yuanfang GuanXiuzhen Huang

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