Bilateral native nephrectomy for refractory hypertension in kidney transplant and kidney pancreas transplant patients

International Journal of Surgery Case Reports
Mark J LermanRonald Aronoff

Abstract

Hypertension is common in renal transplant patients and sometimes very difficult to control. Refractory hypertension can adversely affect renal graft and patient survival. Many antihypertensive medications are not well tolerated or can have important drug interactions with immunosuppressive medications. These drugs can cause significant side effects including fluid depletion, azotemia, electrolyte imbalance, and anemia. Bilateral native nephrectomy in renal transplant patients has been reported to be beneficial in controlling severe hypertension. We report five patients with severe hypertension despite as many as 9 different antihypertensive medications. All patients had previous kidney or simultaneous kidney pancreas transplantation. Each of our patients underwent laparoscopic bilateral native nephrectomy. Renal function varied from creatinine of 1.4-2.4, and the number of antihypertensive medications from 3 to 9 at the time of nephrectomy surgery. Mean arterial blood pressure improved in all five patients at 3-6 months post nephrectomy, the number of antihypertensive medications decreased in 4, but renal function remained stable at 3-6 months in only 3 patients. We found laparoscopic bilateral native nephrectomy to be benefic...Continue Reading

Citations

Mar 28, 2020·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Piotr JarzemskiBartosz Brzoszczyk
Jul 3, 2020·Frontiers in Medicine·Ekamol TantisattamoAlpesh Amin
Dec 31, 2019·Progress in Cardiovascular Diseases·Aashish GuptaJ Stephen Jenkins
May 6, 2021·Journal of Human Hypertension·Charalampos LoutradisCharles J Ferro

❮ Previous
Next ❯

Methods Mentioned

BETA
bilateral
biopsies

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.