PMID: 9436800Jan 22, 1998Paper

Bilateral neuropathologic changes in a child with hemimegalencephaly

Pediatric Neurology
R JahanHarry V Vinters

Abstract

Evaluation of a 7-month-old girl with developmental delay and intractable seizures revealed hemispheric asymmetry and an enlarged right cerebral hemisphere. Because of a history of seizures refractory to medical therapy, she was admitted for right hemispherectomy, but died of complications of surgery. Postmortem brain examination revealed asymmetric enlargement of the right cerebral hemisphere but no gross abnormalities in the left hemisphere. Microscopic examination demonstrated bilateral neuropathologic changes consistent with severe cortical dysplasia in the right cerebral hemisphere and mild cortical dysplasia in the left. Although white matter abnormalities in the unaffected hemisphere have been reported in hemimegalencephaly, bilateral cortical abnormalities, not reported previously in patients with hemimegalencephaly, may account for the varied clinical outcome with medical therapy or after hemispherectomy.

References

Jan 11, 1975·Acta Neuropathologica·R M StewartV S Caviness
Nov 1, 1990·Neuropediatrics·R CusmaiB Echenne
Jun 1, 1988·Brain Research·V H Perry, L Maffei
Jan 1, 1988·AJR. American Journal of Roentgenology·A J BarkovichD Norman
Mar 1, 1988·The Journal of Comparative Neurology·F H GageS Varon
Mar 1, 1988·Neuropathology and Applied Neurobiology·O RobainF Rozenberg
Oct 1, 1987·Radiology·G L KalifaO Robain
Feb 1, 1985·Neuropediatrics·M KingS Galbraith
Jun 1, 1985·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·J J Myers, R W Sperry
Aug 1, 1985·The Journal of Comparative Neurology·J M ProvisP Russell
Jan 1, 1983·Neuroradiology·R A ZimmermanR I Grossman
Oct 10, 1980·Science·D Purves, J W Lichtman
Jul 1, 1994·Journal of Neurosurgery·J M TahaT S Berger
Mar 1, 1995·Journal of Neuropathology and Experimental Neurology·P S MischelH V Vinters

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Citations

Mar 30, 2010·Pediatric Radiology·Mark S ShiroishiAshok Panigrahy
Mar 20, 2010·Acta Neuropathologica·Branavan Manoranjan, John P Provias
Apr 6, 2002·Brain & Development·Taketoshi MaeharaMari Inoue
Jan 26, 2008·The Neurologist·Vicente VillanuevaAntonio Gil-Nagel
Jan 31, 2008·Pediatric Neurosurgery·Ken R WinstonB K Kleinschmidt-DeMasters
Dec 3, 2011·Journal of Neurosurgery. Pediatrics·Cristina V TorresJames T Rutka
Apr 22, 2008·Neuro-Chirurgie·C BulteauO Delalande
Jul 6, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·C Di RoccoL Massimi
Oct 10, 2014·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Antonio Carlos SantosHelio R Machado
Oct 23, 2010·Epilepsy Research·Mitsugu UematsuShigeru Tsuchiya
Apr 7, 2009·Brain & Development·Hiroshi KometaniShin-ichiro Hamano
Apr 12, 2005·Acta Neurologica Scandinavica·S H ErikssonC Nordborg
Feb 28, 2015·Brain : a Journal of Neurology·Laura A JansenWilliam B Dobyns
Sep 15, 2012·Epilepsy Research·Nicolien M van der KolkKees P J Braun
Aug 11, 2007·Seizure : the Journal of the British Epilepsy Association·D LettoriF Guzzetta
Jan 16, 2016·AJNR. American Journal of Neuroradiology·A MeodedA Poretti
Dec 31, 2003·Journal of Child Neurology·Laura Flores-SarnatAntonio Alvarez
Jun 1, 2005·Journal of Child Neurology·Renzo Guerrini, Tiziana Filippi
Dec 31, 2002·Journal of Child Neurology·Paolo GalluzziCarlo Venturi
Aug 2, 2002·Journal of Child Neurology·Laura Flores-Sarnat
Sep 17, 2011·Fetal Diagnosis and Therapy·Rosa María AlvarezGuillermo Antiñolo
Nov 18, 2005·Brain : a Journal of Neurology·Noriko SalamonGary W Mathern
Jul 30, 2003·Journal of Computer Assisted Tomography·Ahmed N AbdelhalimPer-Lennart Westesson
May 29, 2000·Brain : a Journal of Neurology·S M Sisodiya
May 13, 1999·Archives of Pathology & Laboratory Medicine·R A PraysonW Bingaman

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