Bilateral Pulmonary Emboli and Deep Venous Thrombi in Association With Chronic Inflammatory Demyelinating Polyneuropathy.

Curēus
Christine M DohertyRobert Wilson

Abstract

Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune neurological disorder primarily affecting the peripheral nervous system. It is important to recognize because treatment with immunomodulators can improve symptoms. We present the case of a 61-year-old man who developed a saddle pulmonary embolus as well as right-sided deep venous thrombi following left knee arthroplasty. Two months later, he had persistent pre-syncopal symptoms with exertion and had developed paraesthesias in both feet. Invasive cardiopulmonary exercise testing revealed preload failure with no evidence of pulmonary hypertension. He was then referred to neurology where clinical history, physical examination, autonomic battery, and nerve biopsy were consistent with a diagnosis of CIDP with autonomic dysfunction. Extensive venous thromboembolism may be a unique presentation of CIDP. The mechanisms, which may lead to hypercoagulability in CIDP, include the presence of systemic inflammation and denervation of peripheral vasculature leading to stasis.

References

May 14, 2005·Current Opinion in Neurology·Hubertus KöllerHans-Peter Hartung
May 18, 2006·Renal Failure·Kuan-Hsing ChenCheng-Chieh Hung
Oct 10, 2018·Journal of Neurology, Neurosurgery, and Psychiatry·Pietro Emiliano DonedduUNKNOWN Italian CIDP Database study group
May 11, 2019·Journal of Autoimmunity·Yhojan RodríguezJuan-Manuel Anaya

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