PMID: 8971893Dec 1, 1996Paper

Bilateral renal venous thrombosis in a neonate associated with resistance to activated protein C

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
D HaffnerF Schaefer

Abstract

Renal venous thrombosis (RVT) is a serious complication of neonates. In most cases the underlying cause of RVT remains unclear. Here we report a neonate with bilateral RVT and adrenal haemorrhage associated with a heterozygous mutation of the gene encoding for clotting factor V, resulting in resistance to activated protein C. Vigorous thrombolytic therapy with urokinase followed by recombinant tissue plasminogen activator dissolved the thrombus in the inferior vena cava and restored perfusion of both kidneys. However, a haemorrhagic rupture of the right kidney occurred, requiring emergency nephrectomy. Despite reperfusion of the left kidney and resumption of urine output, the patient remained dialysis dependent. Due to persistent adrenal insufficiency, long-term substitution of hydrocortisone was necessary. The patient was prophylactically treated with coumarin during the first 6 months of life and is now waiting for renal transplant at the age of 1 year.

Citations

Sep 14, 2000·Indian Journal of Pediatrics·E ErgenekonC Türkyilmaz
Nov 16, 2007·Cardiovascular and Interventional Radiology·Jawad U KhanHyun S Kim
Feb 9, 2006·Archives of Disease in Childhood. Fetal and Neonatal Edition·P J D WinyardL Rees
Dec 29, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Willem ProesmansChris Van Geet
Aug 26, 2011·Seminars in Fetal & Neonatal Medicine·Leonardo R BrandãoKeith K Lau
Jun 24, 2005·The Journal of Pediatrics·Stephen D MarksVibhuti S Shah
Dec 18, 2001·QJM : Monthly Journal of the Association of Physicians·H SoranD A Taberner
Nov 28, 2001·Hematology·M E AndrewA K Chan
Nov 3, 2007·Pediatrics·Keith K LauUNKNOWN Canadian Pediatric Thrombosis and Hemostasis Network

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