PMID: 9424979Jan 10, 1998Paper

Bilateral sampling of the internal jugular vein to distinguish between mechanisms of adrenocorticotropic hormone-dependent Cushing syndrome

Annals of Internal Medicine
J L DoppmanL K Nieman

Abstract

Bilateral sampling of the petrosal sinuses to distinguish Cushing disease from the ectopic adrenocorticotropic hormone (ACTH) syndrome is accurate but technically demanding and risky. Bilateral sampling of the internal jugular vein is simpler and safer. To compare bilateral internal jugular vein sampling with bilateral inferior petrosal sinus sampling for distinguishing patients with Cushing disease from those with the ectopic ACTH syndrome. Tertiary referral hospital. 20 patients with surgically proven Cushing disease and 1 patient with proven ectopic ACTH syndrome. All patients underwent petrosal sinus sampling and jugular vein sampling before and after administration of corticotropin-releasing hormone (CRH) on separate days. Ratios of central ACTH to peripheral ACTH in petrosal sinus samples and jugular vein samples were calculated before and after administration of CRH. Ratios of central to peripheral ACTH were diagnostic for Cushing disease (> 2 before administration of CRH and > 3 after administration of CRH) in jugular vein samples from 16 of 20 patients with surgically proven Cushing disease (sensitivity, 80% [95% CI, 56% to 96%]). Ten of these 16 patients (63%) had diagnostic results only after CRH was administered. Th...Continue Reading

Citations

Apr 20, 1999·Endocrinology and Metabolism Clinics of North America·J W Findling, H Raff
Sep 27, 2001·Endocrinology and Metabolism Clinics of North America·J W Findling, H Raff
Jul 6, 2000·Journal of Endocrinological Investigation·F Pecori GiraldiF Cavagnini
Jun 9, 2005·European Journal of Endocrinology·Helen L StorrMartin O Savage
Jan 22, 2000·Radiology·P L Choyke, J L Doppman
Apr 27, 2005·Endocrinology and Metabolism Clinics of North America·John R Lindsay, Lynnette K Nieman
Jan 14, 2004·The Korean Journal of Internal Medicine·Hyun Dae Yoon, Ho Sang Shon
May 24, 2016·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Martin G RadvanyRoberto Salvatori
Sep 21, 2010·Interactive Cardiovascular and Thoracic Surgery·Roman DuttaVaishali Suri
Nov 17, 1998·Journal of Neurosurgery·E H Oldfield, J L Doppman
Jun 12, 2004·Neurosurgical Focus·Marie Simard
Nov 24, 2019·The Journal of Clinical Endocrinology and Metabolism·Shi ChenZhaolin Lu
Dec 18, 2013·Journal of Neuro-oncology·Nicholas J Patronas, Chia-Ying Liu
Apr 10, 2019·Journal of the Endocrine Society·Loren Wissner GreeneHershel Raff
May 10, 2000·Journal of Endocrinological Investigation·J W Findling
Jul 1, 2020·The Journal of Clinical Endocrinology and Metabolism·Caroline FreteAntoine Tabarin
Jul 8, 2008·Arquivos brasileiros de endocrinologia e metabologia·Paulo PugliaLuis R Salgado
Jan 10, 2021·The Journal of Clinical Endocrinology and Metabolism·Jordan E PerlmanAmir H Hamrahian

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