Bilateral Subthalamic Stimulation can Improve Sleep Quality in Parkinson's Disease

Journal of Parkinson's Disease
Gabriella DeliNorbert Kovács

Abstract

Sleep problems are among the most common non-motor symptoms of Parkinson's disease (PD). The PD Sleep Scale 2nd version (PDSS-2) improved the original PDSS by adding more items on different aspects of sleep problems, making it a more robust tool to evaluate the severity of sleep disturbances. However, previous studies on deep brain stimulation (DBS) have not used the PDSS-2. To determine if the PDSS-2 could detect improvement reliably in sleep problems after bilateral subthalamic nucleus DBS for PD. In this prospective study, 25 consecutive patients undergoing DBS implantation were enrolled. Patients were examined twice: 1 week prior to the DBS implantation (baseline) and 12 months postoperatively. Severity of PD symptoms were assessed by the Movement Disorders Society Unified PD Rating Scale (MDS-UPDRS) and the Non-Motor Symptoms Scale (NMSS). Presence and severity of sleep disturbances were specifically measured by PDSS-2. Total score of MDS-UPDRS improved from 81 (median, interquartile-range: 63-103) to 55 points (median, IQR: 46-75, p <  0.001). Health-related quality of life, measured by PDQ-39, also improved from 29 (IQR: 18-40) to 15 (IQR: 9-28) points (p = 0.002). Most domains of NMSS also improved. At baseline 13 patie...Continue Reading

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Citations

Mar 12, 2016·Journal of Neurology·Elena LezcanoJuan José Zarranz
Nov 6, 2015·Parkinson's Disease·Krisztina HorváthNorbert Kovács
Apr 10, 2017·European Neurology·Annamária JuhászNorbert Kovács
Feb 22, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Krisztina HorváthNorbert Kovács
Mar 1, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Attila MakkosNorbert Kovács
Dec 24, 2019·Journal of Parkinson's Disease·Dávid PintérNorbert Kovács
Apr 7, 2020·Journal of Parkinson's Disease·José Rafael P Zuzuárregui, Jill L Ostrem
Oct 31, 2017·Behavioural Neurology·Márton KovácsNorbert Kovács
Sep 14, 2018·Frontiers in Neurology·Vibhash D SharmaAmy W Amara
Oct 9, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·José Rafael P Zuzuárregui, Emmanuel H During

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Methods Mentioned

BETA
MDS

Software Mentioned

NMSS
PDSS
SPSS

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