Bilateral synchronous adrenal metastases of renal cell carcinoma: A case report and review of the literature

Oncology Letters
Hakan Ozturk

Abstract

Renal cell carcinomas (RCCs) metastasize to the adrenal glands via various mechanisms, including lymphatic vessel arterial embolism and retrograde venous embolism. The rate of ipsilateral metastasis is 3-5% and the rate of contralateral metastasis is ~0.7%, however, synchronous bilateral adrenal metastases are extremely rare. Therefore, the optimal diagnosis and treatment strategy for this condition is yet to be thoroughly defined. In the present study, a 50-year-old male patient presented with right flank pain. Ultrasonography (US) revealed a right renal mass and bilateral adrenal metastases, and a computerized tomography (CT) scan determined the size of the lesions: An 86×83×66-mm mass in the lower pole of the right kidney, an 18×12×10-mm mass in the right adrenal gland, and a 69×51×53-mm mass in the left adrenal gland with central necrosis and peripheral contrast uptake. A US-guided biopsy was performed which determined a diagnosis of right RCC and bilateral synchronous adrenal metastasis. Immunohistochemical examination of the biopsy revealed clear cell carcinoma (Fuhrman grade, III). Consequently, right radical nephrectomy, right partial adrenalectomy (with frozen section examination) and left adrenalectomy were planned. T...Continue Reading

References

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Citations

Nov 4, 2015·International Urology and Nephrology·Corey CostantinoMegan L Troxell
Nov 4, 2017·Journal of Endourology Case Reports·Akbar NouralizadehFahad Khalid Radhi
Apr 29, 2016·Molecular and Clinical Oncology·Tao HeYongqing Lai
May 12, 2018·European Journal of Endocrinology·Isabelle BourdeauAndré Lacroix
Jan 10, 2020·CEN Case Reports·Asaad MoradiReza Dehghaniathar
Sep 20, 2017·Bioscience Reports·Zheng MaZhonghua Xu
Sep 16, 2016·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Stavroula A PaschouAndromachi Vryonidou

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Methods Mentioned

BETA
biopsy
biopsies

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