Bilateral temporal hypometabolism in epilepsy

Epilepsia
D E BlumR S Fisher

Abstract

Positron emission tomography (PET) has proven useful in epilepsy surgery for its ability to identify unilateral temporal hypometabolism (UTH), which is predictive of good surgical outcome. The significance of bilateral temporal hypometabolism (BTH) is not known. We identified all patients who had marked bilateral reduction in temporal lobe metabolism relative to the cerebellar hemispheres and compared their clinical features and treatment outcomes with those of control patients with UTH. BTH was evident in 10% of PET scans for epilepsy at our institution. We compared these patients with age-matched controls with UTH. The BTH patients had a higher percentage of generalized seizures; were more likely to have bilateral, diffuse or extratemporal seizure onsets; and had bilateral or diffuse magnetic resonance imaging (MRI) findings. UTH patients were more likely to have unilateral mesial temporal atrophy on MRI. Even when electrical seizure onsets were well localized, surgical outcomes were markedly worse in these patients than in controls. Medical treatment was also less successful. Social and cognitive functioning was worse in the BTH group. The only death occurred in the group with BTH. Patients with BTH have features distinct fr...Continue Reading

References

Dec 1, 1992·Annals of Neurology·W H TheodoreD B Leiderman
Jun 17, 1988·Science·M I PosnerM E Raichle
Jul 1, 1987·Epilepsia·W H TheodoreM Deitz
Sep 1, 1993·Annals of Epidemiology·T J Thom
Apr 1, 1994·Australian Veterinary Journal·P G AllinghamD H Kemp
Jul 1, 1994·Epilepsia·S S Spencer, D D Spencer
Nov 1, 1993·The American Journal of Medicine·P D Waite
Oct 1, 1993·Neurology·R C FrysingerR M Harper
Jun 1, 1993·Archives of Neurology·T R HenryJ Engel

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Citations

Jan 31, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Joon Young ChoiSang Eun Kim
May 21, 2003·Seminars in Nuclear Medicine·Thomas R Henry, Ronald L Van Heertum
Sep 22, 2001·Journal of Neurosurgery·H Rafael, R Mego
Apr 19, 2007·Neurological Research·Kimiaki HashiguchiTomio Sasaki
Mar 14, 2013·Expert Opinion on Medical Diagnostics·Clarissa Lin Yasuda, Fernando Cendes
Apr 1, 2010·PET Clinics·Abass Alavi, Andrew B Newberg
Jan 14, 2012·Annals of the New York Academy of Sciences·Abass AlaviAndrew B Newberg
Jul 15, 1999·Seminars in Pediatric Neurology·K K MohanH T Chugani
Feb 8, 2005·Radiologic Clinics of North America·Andrew B Newberg, Abass Alavi
Aug 25, 2004·Neuroimaging Clinics of North America·Thomas R Henry, John R Votaw
Aug 21, 2007·Seminars in Nuclear Medicine·Shekhar PatilLise Borgwardt
May 29, 2007·Seizure : the Journal of the British Epilepsy Association·O WillmannB Pohlmann-Eden
Jan 25, 2011·Epilepsy & Behavior : E&B·Thomas R Henry, Deborah D Roman
Jul 30, 2011·Epilepsy & Behavior : E&B·Aaron F StruckDouglas A Dulli
Mar 1, 2003·Epilepsy & Behavior : E&B·Amee D. BairdDavid C. Reutens
Sep 10, 2016·Journal of Neurosurgery. Pediatrics·Tatjana Traub-WeidingerMartha Feucht
Jan 5, 2019·Annals of Neurology·Varduhi CahillTerence J O'Brien
Oct 30, 2019·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Zeenat JaisaniArie L Weinstock
Jan 14, 2021·International Journal of Environmental Research and Public Health·Manar IbdaliPriya D Shanmugarajah
Aug 12, 2020·Seizure : the Journal of the British Epilepsy Association·Baotian ZhaoKai Zhang

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