Bilateral volume reduction in posterior hippocampus in psychosis of epilepsy

Journal of Neurology, Neurosurgery, and Psychiatry
James AlleboneSarah J Wilson

Abstract

Psychosis of epilepsy (POE) occurs more frequently in temporal lobe epilepsy, raising the question as to whether abnormalities of the hippocampus are aetiologically important. Despite decades of investigation, it is unclear whether hippocampal volume is reduced in POE, perhaps due to small sample sizes and methodological limitations of past research. In this study, we examined the volume of the total hippocampus, and the hippocampal head, body and tail, in a large cohort of patients with POE and patients with epilepsy without psychosis (EC). One hundred adults participated: 50 with POE and 50 EC. Total and subregional hippocampal volumes were manually traced and compared between (1) POE and EC; (2) POE with temporal lobe epilepsy, extratemporal lobe epilepsy and generalised epilepsy; and (3) patients with POE with postictal psychosis (PIP) and interictal psychosis (IP). Compared with EC the POE group had smaller total left hippocampus volume (13.5% decrease, p<0.001), and smaller left hippocampal body (13.3% decrease, p=0.002), and left (41.5% decrease, p<0.001) and right (36.4% decrease, p<0.001) hippocampal tail volumes. Hippocampal head volumes did not differ between groups. Posterior hippocampal volumes are bilaterally redu...Continue Reading

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Dec 25, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·James AlleboneSarah J Wilson

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Citations

Mar 7, 2021·International Journal of Molecular Sciences·Wieke M van Oostveen, Elizabeth C M de Lange
Jul 1, 2020·L'Encéphale·B de ToffolC Hingray
Dec 10, 2021·Continuum : Lifelong Learning in Neurology·Parunyou Julayanont, Uma Suryadevara

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