Bilaterally evoked monosynaptic EPSPs, NMDA receptors and potentiation in rat sympathetic preganglionic neurones in vitro

The Journal of Physiology
David SpanswickS D Logan

Abstract

1. Whole-cell patch clamp and intracellular recordings were obtained from 190 sympathetic preganglionic neurones (SPNs) in spinal cord slices of neonatal rats. Fifty-two of these SPNs were identified histologically as innervating the superior cervical ganglion (SCG) by the presence of Lucifer Yellow introduced from the patch pipette and the appearance of retrograde labelling following the injection of rhodamine-dextran-lysine into the SCG. 2. Electrical stimulation of the ipsilateral (n = 71) or contralateral (n = 32) lateral funiculi (iLF and cLF, respectively), contralateral intermediolateral nucleus (cIML, n = 41) or ipsilateral dorsal horn (DH, n = 34) evoked EPSPs or EPSCs that showed a constant latency and rise time, graded response to increased stimulus intensity, and no failures, suggesting a monosynaptic origin. 3. In all neurones tested (n = 60), fast rising and decaying components of EPSPs or EPSCs evoked from the iLF, cLF, cIML and DH in response to low-frequency stimulation (0.03-0.1 Hz) were sensitive to non-NMDA receptor antagonists. 4. In approximately 50 % of neurones tested (n = 29 of 60), EPSPs and EPSCs evoked from the iLF, cLF, cIML and DH during low-frequency stimulation were reduced by NMDA receptor antag...Continue Reading

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Citations

Mar 8, 2002·Neuroscience·M C JiangUNKNOWN Department of Physiology, Institute for Neuroscience, Northwestern University Medical School, 303 E. Chicago Avenue, Chicago
Jul 28, 2001·Autonomic Neuroscience : Basic & Clinical·J E Smith
Oct 31, 2009·PLoS Pathogens·Kelly M McCarthyLynn W Enquist
Jan 7, 2006·The Journal of Physiology·Nephtali MarinaMichael P Gilbey
Dec 17, 2002·The Journal of Physiology·Jennifer M M WilsonDavid Spanswick
Jul 9, 2010·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Lu-Yang JiangMao-Tsun Lin
Jun 16, 2009·Journal of Chemical Neuroanatomy·Ida J Llewellyn-Smith
Nov 16, 2012·Autonomic Neuroscience : Basic & Clinical·Ayaka TanabeIkuo Homma
Dec 15, 2007·Frontiers in Neuroendocrinology·Joanna L SpencerBruce S McEwen
Dec 16, 2005·Journal of Neurophysiology·Andrew D WhymentDavid Spanswick
Jun 8, 2001·The Journal of Comparative Neurology·I J Llewellyn-Smith, L C Weaver

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