Bilayer phase transitions of N-methylated dioleoylphosphatidylethanolamines under high pressure

Chemistry and Physics of Lipids
Masataka KusubeShoji Kaneshina

Abstract

The bilayer phase transitions of four kinds of unsaturated phospholipids with different-sized polar head groups, dioleoylphosphatidylethanolamine (DOPE), dioleoylphosphatidyl-N-methylethanolamine (DOMePE), dioleoylphosphatidyl-N,N-dimethylethanolamine (DOMe2PE) and dioleoylphosphatidylcholine (DOPC), were observed by means of differential scanning calorimetry (DSC) and high-pressure light-transmittance. DSC thermogram and light-transmittance curve for each phospholipid vesicle solution exhibited only one phase transition under ambient pressure, respectively. The light-transmittance of DOPC solution at pressure higher than 234 MPa abruptly increased stepwise at two temperatures, which corresponds to the appearance of stable subgel and lamellar gel phases under high pressure in addition to the liquid crystal phase. The constructed temperature (T)-pressure (p) phase diagrams were compared among these phospholipids. The phase-transition temperatures of the phospholipids decreased stepwise by N-methylation of the head group. The slops of the T-p phase boundary (dT/dp) of DOPE, DOMePE and DOMe2PE bilayers (0.127-0.145 K MPa-1) were found to be close to that of the transition from the lamellar crystal (or subgel; Lc) phase to the liqu...Continue Reading

References

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Jan 27, 2005·Biochimica Et Biophysica Acta·Masataka KusubeShoji Kaneshina

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Citations

Jan 26, 2013·International Journal of Molecular Sciences·Hitoshi MatsukiNobutake Tamai
Jan 10, 2012·Colloids and Surfaces. B, Biointerfaces·Nobutake TamaiShoji Kaneshina
Apr 9, 2008·Chemistry and Physics of Lipids·Kaori TadaShoji Kaneshina
Mar 18, 2010·Annals of the New York Academy of Sciences·Kaori TadaShoji Kaneshina
Dec 19, 2006·Biochimica Et Biophysica Acta·Sukit Leekumjorn, Amadeu K Sum
Dec 22, 2010·Chemistry and Physics of Lipids·Nicholas J BrooksJohn M Seddon
Jan 15, 2011·Colloids and Surfaces. B, Biointerfaces·Masaki GotoShoji Kaneshina
Jan 11, 2011·Colloids and Surfaces. B, Biointerfaces·Masaki GotoHitoshi Matsuki
Apr 28, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Masaki GotoShoji Kaneshina
Apr 4, 2017·Biochimica Et Biophysica Acta. Biomembranes·Hitoshi MatsukiShoji Kaneshina
Aug 25, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Agnieszka BroniecHitoshi Matsuki
Jan 26, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Masaki GotoShoji Kaneshina

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