Bile acid binding resin prevents fat accumulation through intestinal microbiota in high-fat diet-induced obesity in mice

Metabolism: Clinical and Experimental
Yukie KusumotoHiroshi Itoh

Abstract

Bile acid binding resin (BAR) absorbs intestinal bile acids, and improves obesity and metabolic disorders, but the precise mechanism remains to be clarified. Recent findings reveal that obesity is associated with skewed intestinal microbiota. Thus, we investigated the effect of BAR on intestinal microbiota and the role of microbiota in the prevention of obesity in high-fat diet-induced obesity in mice. Male Balb/c mice were fed a low-fat diet (LFD), high-fat diet (HFD), or HFD with BAR (HFD+BAR), and then metabolic parameters, caecal microbiota, and metabolites were investigated. The same interventions were conducted in germ-free and antibiotic-treated mice. The frequency of Clostridium leptum subgroup was higher in both HFD-fed and HFD+BAR-fed mice than in LFD-fed mice. The frequency of Bacteroides-Prevotella group was lower in HFD-fed mice than in LFD-fed mice, but the frequency was higher in HFD+BAR-fed mice than in HFD-fed mice. Caecal propionate was lower in HFD-fed mice than in LFD-fed mice, and higher in HFD+BAR-fed mice than in HFD-fed mice. HFD+BAR-fed mice showed lower adiposity than HFD-fed mice, and the reduction was not observed in germ-free or antibiotic-treated mice. Colonized germ-free mice showed a reduction in...Continue Reading

Citations

Aug 1, 2020·Journal of Diabetes Research·Yingjie WuLinjing Zhang
Jul 28, 2018·Journal of Immunology Research·Yuze YuanFang Wang
Dec 18, 2020·Current Opinion in Lipidology·Manon BalversMax Nieuwdorp
May 29, 2021·Molecular and Cellular Endocrinology·Victoria Fernández-GarcíaLisardo Boscá
Jul 18, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Victoria Fernández-GarcíaLisardo Boscá

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