Bile acid metabolism in familial dysbetalipoproteinaemia: studies in subjects with the apolipoprotein E-2/2 phenotype

European Journal of Clinical Investigation
B AngelinK Einarsson

Abstract

Bile acid kinetics and biliary lipid composition were determined in seven subjects with primary dysbetalipoproteinaemia. They were all homozygous for the apolipoprotein E isoform E-2 and six of them were hyperlipidaemic (type III hyperlipoproteinaemia). With or without hyperlipidaemia, the apo E-2/2 phenotype was associated with increased bile acid formation (mean increase compared with 32 normolipidaemic controls, 43%; P less than 0.025). The biliary lipid composition was not different from that seen in the controls. The results indicate that the uptake by the liver of apo E-containing remnant particles is of importance for the regulation of hepatic cholesterol metabolism in man. It is suggested that hepatic cholesterol synthesis is stimulated in dysbetalipoproteinaemia, and that this leads to a compensatory increase in bile acid synthesis.

References

Aug 23, 1977·Biochimica Et Biophysica Acta·L Holmquist, K Carlson
Jul 1, 1977·Canadian Journal of Biochemistry·B RubensteinG Steiner
Jun 1, 1979·Digestive Diseases and Sciences·J AhlbergB Leijd
Apr 1, 1986·European Journal of Clinical Investigation·B Angelin, L A Carlson
Jan 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J DavignonC F Sing
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·B AngelinJ D Brunzell
Dec 1, 1987·The Journal of Clinical Investigation·M S WeintraubJ L Breslow
Aug 1, 1987·The Journal of Clinical Investigation·Y A KesäniemiT A Miettinen
Aug 1, 1985·The New England Journal of Medicine·K EinarssonB Angelin
Feb 1, 1983·European Journal of Clinical Investigation·B AngelinB Leijd
Sep 17, 1957·Acta Physiologica Scandinavica·S LINDSTEDT

❮ Previous
Next ❯

Citations

May 29, 2004·Current Opinion in Lipidology·Silvana ZanlungoFlavio Nervi
Nov 1, 1991·The Journal of Clinical Investigation·T DemantJ Shepherd
Mar 10, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Silvana Zanlungo, Attilio Rigotti
Aug 1, 1996·Scandinavian Journal of Gastroenterology·C Hahn, K von Bergmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.