PMID: 3749801Jun 1, 1986Paper

Bile acid metabolism in patients with Crohn's disease in terminal ileum

Scandinavian Journal of Gastroenterology
L TougaardV Binder

Abstract

Bile acid metabolism was studied by means of the fractional turnover rate or orally ingested 14C-labeled taurocholic acid and by gas chromatographic determination of fecal excretion of the bile acids cholic acid (CA), chenodeoxycholic acid (CDCA), deoxycholic acid (DCA), and lithocholic acid (LCA). Thirty patients with Crohn's disease (CD) of the small bowel, of whom 19 had been operated on with limited ileal resections, were studied and compared with 11 healthy volunteers. The unoperated group of CD patients did not show significant increase in bile acid excretion in the stools in contrast to the CD patients with ileal resection. The fecal excretion consisted mostly of primary bile acids, and a significant correlation between length of resection and bile acid excretion was found (rs = 0.81, p less than 0.01). The fractional turnover rate of CA + DCA was significantly increased in both unoperated (0.21 l/day) and operated (0.44 l/day) patients compared with normal controls (0.06 l/day). The bile acid pool of CA + DCA, however, was normal in patients with ileal resections, indicating a compensatory increase in bile acid synthesis. In unoperated patients the bile acid pool of CA + DCA was slightly decreased (3.1 mmol) compared wi...Continue Reading

References

May 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·B GieseL Thousig
Oct 1, 1985·Scandinavian Journal of Gastroenterology·B H PedersenV Binder
Mar 8, 1980·Lancet·R F Harvey, J M Bradshaw
Jun 1, 1983·European Journal of Clinical Investigation·R FiasseC Dive
Oct 1, 1983·Scandinavian Journal of Gastroenterology·H BothV Binder
Apr 1, 1982·European Journal of Clinical Investigation·P RutgeertsG Vantrappen
Sep 17, 1957·Acta Physiologica Scandinavica·S LINDSTEDT

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Citations

Apr 2, 1998·Journal of Pediatric Gastroenterology and Nutrition·T FujisawaH Kato
Jun 9, 2001·Journal of Pediatric Gastroenterology and Nutrition·B L Shneider
Jun 6, 2009·Journal of Lipid Research·Paul A DawsonAnuradha Rao
Sep 3, 2011·PloS One·Rian M NijmeijerUNKNOWN Dutch Initiative on Crohn, Colitis (ICC)
Oct 21, 2005·Journal of Lipid Research·Ina BergheimEduard F Stange
Jun 27, 2014·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jörg JahnelMichael Trauner
Jan 1, 1996·Scandinavian Journal of Gastroenterology. Supplement·E Krag, E H Thaysen
Jan 6, 2021·Inflammatory Bowel Diseases·Na LiXiaojun Zhuang

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