Bile acid pattern in human amniotic fluid

European Journal of Clinical Investigation
G DélèzeD Sidiropoulos

Abstract

Individual bile acids were determined in twenty-nine amniotic fluid specimens obtained from twenty-six women between the 32nd and 41st week of gestation. Total bile acid concentration ranged from 0.4 to 4.8 mumol/l with a mean of 1.57 mumol/l. Besides the two major bile acids of man, cholic acid and chenodeoxycholic acid, 3beta-hydroxy-5-cholenoic acid was found in all, lithocholic acid in ten and deoxycholic acid in nine of the twenty-nine amniotic fluid samples. 3beta-Hydroxy-5-cholenoic acid averaged 39.8% of total bile acids during 32-37 weeks of gestation and 20.2% at term (P less than 0.01). These findings point towards important differences between fetal and adult bile metabolism and may reflect maturation of hepatic bile acid biosynthesis near term.

References

Jan 1, 1975·Advances in Enzyme Regulation·C A Villee, J M Loring
Jan 1, 1972·Annual Review of Medicine·A Milunsky, J W Littlefield
Jan 1, 1968·Biochemistry·H Danielsson, W J Rutter
Oct 1, 1974·The American Journal of Digestive Diseases·E H Mosbach, G Salen
Mar 14, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·P Back
Jan 1, 1973·Hoppe-Seyler's Zeitschrift für physiologische Chemie·P Back, K Ross
Jan 1, 1972·The Journal of Clinical Investigation·K E AndersonN B Javitt
Feb 1, 1971·American Journal of Obstetrics and Gynecology·L GluckW N Spellacy
Oct 1, 1956·Biochimica Et Biophysica Acta·D S FREDRICKSON, K ONO
Jun 1, 1963·Analytical Biochemistry·M MAKITA, W W WELLS
Dec 1, 1961·American Journal of Obstetrics and Gynecology·A W LILEY

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Citations

Feb 15, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·A HernanzC Diaz
Oct 1, 1983·Toxicology Letters·B TuchweberI M Yousef
Dec 9, 2000·Biochimica Et Biophysica Acta·N B Javitt
Sep 1, 1981·The Journal of Clinical Investigation·S BarnesG Cassady
Nov 1, 1982·The Journal of Clinical Investigation·Y AmuroJ Sato
May 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M LewittesI M Yousef
Aug 1, 1982·European Journal of Clinical Investigation·B Strandvik, S A Wikström
Feb 1, 1994·Scandinavian Journal of Clinical and Laboratory Investigation·B StrandvikS A Wikström
Jan 1, 1982·Acta Paediatrica Scandinavica. Supplement·B Strandvik
Sep 1, 1985·Journal of Clinical Ultrasound : JCU·P JouppilaP Kirkinen
Apr 24, 2002·Biochemical and Biophysical Research Communications·Norman B Javitt

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