PMID: 9434100Jan 20, 1998Paper

Bile acid secretion during synchronized rat liver regeneration

Biochimica Et Biophysica Acta
M J MonteJose J G Marin

Abstract

One major difficulty in interpreting the changes occurring during liver regeneration is the co-existence of non-activated cells and proliferating hepatocytes at all stages of differentiation. The aim of this study was to investigate bile acid (BA) secretion into bile during normal (NLR) and synchronized (SLR) liver regeneration in rats. Regeneration was synchronized by reversible inhibition of ribonucleotide reductase by 10 h treatment with hydroxyurea (HU) shortly after two-third partial hepatectomy. Total BA output as measured by GC-MS increased immediately after partial hepatectomy. This was followed by a further transient enhancement during the next day in the NLR. HU treatment did not significantly modify total BA output, but after releasing synchronized regeneration a marked reduction was observed. This was followed by a recovery to reach values close to those of NLR on day 7 of the regenerative process in SLR. Amidated BA output as measured by HPLC analysis revealed an early enhancement in the proportion of non-conjugated BAs in bile in NLR. However, the profile of conjugated BAs, which was not affected by HU treatment, matched that of total BAs during the first stage of SLR. By contrast, the increase in BA output observ...Continue Reading

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Citations

Apr 12, 2002·Journal of Hepatology·Maria J MonteJose J G Marin
Mar 1, 2000·Biochemical and Biophysical Research Communications·G BruscalupiA Trentalance
Feb 9, 2006·The Journal of Surgical Research·Shun-ichi TanakaYorio Maeda
Jan 9, 2003·Journal of Lipid Research·Maria E MendozaJose J G Marin
May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T A VosM Müller
Oct 1, 2008·Cell Research·Yan-Dong WangWendong Huang
May 31, 2003·Placenta·J J G MarinM A Serrano
Sep 10, 2017·Biochimica Et Biophysica Acta. Biomembranes·Stephanie J ShiffkaPeter W Swaan

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