PMID: 3758817Sep 1, 1986Paper

Bile acid secretion in cystic fibrosis: evidence for a defect unrelated to fat malabsorption

Gut
Z WeizmanG G Forstner

Abstract

In order to define basic biliary defects not related to steatorrhoea in cystic fibrosis, we studied 12 control and 18 cystic fibrosis subjects, with a wide range of pancreatic function. Duodenal aspirates were collected over three consecutive 20 minute periods, during continuous intravenous infusion of cholecystokinin and secretin using a marker perfusion technique, and analysed for pancreatic enzyme output (colipase, lipase, trypsin), bile acid output and concentration, and biliary lipids. Cystic fibrosis patients, at all levels of pancreatic function, had significantly reduced total bile acid output (mumol/kg/h) with delayed appearance of the bile acid peak, compared with control subjects. Actual duodenal bile acid concentrations were significantly higher in cystic fibrosis subjects than in controls, however, probably because of the markedly reduced water output shown in these patients. The lithogenic index was not raised in cystic fibrosis patients at any level of pancreatic function. The reduced bile acid output and the delayed peak appearance probably reflect a defect in gall bladder responsiveness which is independent of pancreatic function and steatorrhoea. Whether this defect is related to gall bladder filling or a defe...Continue Reading

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Citations

Apr 1, 1997·Irish Journal of Medical Science·D S McGrathR Meeke
Jul 1, 1996·Journal of Hepatology·B StrandvikB Angelin
Apr 23, 2002·Journal of Gastroenterology and Hepatology·Piotr MilkiewiczElwyn Elias
Apr 1, 1995·Archives of Disease in Childhood·M S Tanner, C J Taylor
Nov 1, 1987·Gut·P L Zentler-Munro
Apr 1, 1987·Gut·G P Davidson, T A Robb
Jun 25, 1998·Disability and Rehabilitation·J L Murphy, S A Wootton
Oct 29, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·P M van HasseltC F van Nostrum
Nov 1, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ian GoodingDavid Westaby
Nov 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M AngelicoM Antonelli
Feb 21, 2018·Pediatric Pulmonology·Benjamin T KoppDon Hayes
Sep 5, 2019·Molecular Nutrition & Food Research·Barbara WaltherGuy Vergères
Jan 1, 1989·Acta Paediatrica Scandinavica. Supplement·P R Durie
Jul 27, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Sławomira Drzymała-CzyżJarosław Walkowiak

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