Jul 31, 2014

Bile acid signaling in metabolic disease and drug therapy

Pharmacological Reviews
Tiangang Li, John Y L Chiang

Abstract

Bile acids are the end products of cholesterol catabolism. Hepatic bile acid synthesis accounts for a major fraction of daily cholesterol turnover in humans. Biliary secretion of bile acids generates bile flow and facilitates hepatobiliary secretion of lipids, lipophilic metabolites, and xenobiotics. In the intestine, bile acids are essential for the absorption, transport, and metabolism of dietary fats and lipid-soluble vitamins. Extensive research in the last 2 decades has unveiled new functions of bile acids as signaling molecules and metabolic integrators. The bile acid-activated nuclear receptors farnesoid X receptor, pregnane X receptor, constitutive androstane receptor, vitamin D receptor, and G protein-coupled bile acid receptor play critical roles in the regulation of lipid, glucose, and energy metabolism, inflammation, and drug metabolism and detoxification. Bile acid synthesis exhibits a strong diurnal rhythm, which is entrained by fasting and refeeding as well as nutrient status and plays an important role for maintaining metabolic homeostasis. Recent research revealed an interaction of liver bile acids and gut microbiota in the regulation of liver metabolism. Circadian disturbance and altered gut microbiota contrib...Continue Reading

  • References395
  • Citations124

References

Mentioned in this Paper

Metabolic Process, Cellular
Pathogenic Aspects
VDR gene
Bile Acid Measurement
Pathogenesis
Derivatives
Cholesterol Catabolic Process
G-Protein-Coupled Receptors
Energy Metabolism
RNA, Small Temporal

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