PMID: 3768399Nov 14, 1986Paper

Bile acid structure and bile formation in the guinea pig

Biochimica Et Biophysica Acta
N Tavoloni

Abstract

The effects of intravenous infusions (1-4 mumol/min/kg) of 14 bile acids, cholic, deoxycholic, ursodeoxycholic, chenodeoxycholic, dehydrocholic, and their glycine and taurine conjugates, on bile flow and composition and on the biliary permeation of inert carbohydrates have been studied in the guinea pig bile fistula. Hydroxy bile acids were eliminated in bile without major transformation, except for conjugation (over 90%) when unconjugated bile acids were infused. During infusion of dehydrocholate and taurodehydrocholate, 77-100% of the administered dose was recovered in bile as 3-hydroxy bile acids, thus indicating that reduction of the keto group in position 3 was virtually complete. All bile acids produced choleresis at the doses employed: the strongest choleretic was deoxycholate (81.78 microliters/mumol), the weakest was taurodehydrocholate (10.2 microliters/mumol). Choleretic activity was directly and linearly related to bile acid hydrophobicity, as inferred by HPLC, both for similarly conjugated bile acids, and for bile acids having the same number, position, or configuration of the hydroxyl groups. In all instances, the rank ordering was: deoxycholate greater than chenodeoxycholate greater than cholate greater than urso...Continue Reading

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Citations

Aug 1, 1995·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·F GuertinB Tuchweber
Jun 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H J VerkadeF Kuipers
May 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R UtiliH J Zimmerman
Aug 3, 2005·Journal of Lipid Research·Antonio MoschettaAlan F Hofmann

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