Bile Acid sulfation: a pathway of bile acid elimination and detoxification

Toxicological Sciences : an Official Journal of the Society of Toxicology
Yazen Alnouti

Abstract

Sulfotransferase-2A1 catalyzes the formation of bile acid-sulfates (BA-sulfates). Sulfation of BAs increases their solubility, decreases their intestinal absorption, and enhances their fecal and urinary excretion. BA-sulfates are also less toxic than their unsulfated counterparts. Therefore, sulfation is an important detoxification pathway of BAs. Major species differences in BA sulfation exist. In humans, only a small proportion of BAs in bile and serum are sulfated, whereas more than 70% of BAs in urine are sulfated, indicating their efficient elimination in urine. The formation of BA-sulfates increases during cholestatic diseases. Therefore, sulfation may play an important role in maintaining BA homeostasis under pathologic conditions. Farnesoid X receptor, pregnane X receptor, constitutive androstane receptor, and vitamin D receptor are potential nuclear receptors that may be involved in the regulation of BA sulfation. This review highlights current knowledge about the enzymes and transporters involved in the formation and elimination of BA-sulfates, the effect of sulfation on the pharmacologic and toxicologic properties of BAs, the role of BA sulfation in cholestatic diseases, and the regulation of BA sulfation.

References

Feb 10, 1978·Biochimica Et Biophysica Acta·L J ChenR J Bolt
Aug 1, 1978·American Journal of Orthodontics·B Schwaninger
Feb 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·S T CarbonettoK J Muller
Jul 1, 1979·Digestive Diseases and Sciences·H S MekhjianA F Hofmann
Jun 15, 1979·Experientia·R Drew, B G Priestly
Jan 1, 1979·Scandinavian Journal of Gastroenterology·L Lööf, B Wengle
Jan 1, 1977·Clinical Science and Molecular Medicine·J A SummerfieldB H Billing
Sep 28, 1978·Biochimica Et Biophysica Acta·L Lööf, B Wengle
Nov 1, 1978·Chest·J C McMichan, L Michel
Sep 1, 1977·The Journal of Clinical Investigation·R Galeazzi, N B Javitt
Jul 15, 1977·The Biochemical Journal·S BarnesB H Billing
Sep 1, 1977·Life Sciences·H EyssenG Janssen
May 15, 1976·The Biochemical Journal·J A SummerfieldB H Billing
Jul 15, 1976·European Journal of Biochemistry·H J EyssenJ A Mertens
Jan 1, 1976·Transactions of the Royal Society of Tropical Medicine and Hygiene·C C Draper
Nov 1, 1975·American Journal of Orthodontics·B U Zachrisson, I A Mjör
Sep 16, 1975·Clinica Chimica Acta; International Journal of Clinical Chemistry·C B CampbellL W Powell
Oct 1, 1975·Analytical Biochemistry·J A Peterson, D M Mock
Jan 30, 1976·European Journal of Clinical Investigation·W Fröhling, A Stiehl
Feb 1, 1976·Journal of the National Cancer Institute·B S ReddyE L Wynder
Aug 31, 1992·Biochemical and Biophysical Research Communications·A N KongT D Bjornsson
Mar 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I YousefB Tuchweber
Mar 29, 1991·Biochemical and Biophysical Research Communications·M Runge-Morris, J Wilusz
Sep 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R L FisherS P Lan
Oct 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M LittleR Lester
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B HagenbuchP J Meier
Jan 10, 1991·Biochimica Et Biophysica Acta·C M GarnerJ M Neuberger
Oct 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·U GärtnerA W Wolkoff
Oct 1, 1990·International Journal of Dermatology·B B Furner
Nov 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·B Chatterjee, A K Roy
Dec 15, 1990·The Biochemical Journal·A RadominskaC N Falany

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Citations

Nov 12, 2013·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Sai Praneeth R BathenaYazen Alnouti
Jun 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Chu-Yin YehWeiming Li
Jan 24, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rama PaiDonna Dambach
Nov 2, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jagadeesha K Dammanahalli, Michael W Duffel
Jun 28, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·M Andrea Azcárate-PerilJosé M Bruno-Bárcena
Jul 31, 2010·Journal of Lipid Research·Youcai Zhang, Curtis D Klaassen
May 18, 2013·Biochimica Et Biophysica Acta·Eija M SelkäläKaija J Autio
Mar 5, 2014·Expert Opinion on Drug Metabolism & Toxicology·Manuela de Lima Toccafondo Vieira, Carlos Alberto Tagliati
Sep 13, 2013·Drug Metabolism Reviews·Susumu Kodama, Masahiko Negishi
Jan 22, 2013·Drug Metabolism Reviews·Melissa Runge-MorrisCharles N Falany
Feb 15, 2016·Clinics and Research in Hepatology and Gastroenterology·Heiko S SchadtGerd A Kullak-Ublick
Apr 19, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Nakayuki NaritakaToshiaki Shimizu
May 7, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Priya VijayvargiyaAmy Saenger
Feb 2, 2010·Physiological and Biochemical Zoology : PBZ·Lee R HageyMatthew D Krasowski
Mar 23, 2011·Seminars in Cell & Developmental Biology·Paul A Dawson
Aug 9, 2015·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Allison M ChurcherAdelino V M Canário
Nov 22, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Youcai ZhangCurtis D Klaassen
Dec 20, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yasuaki Takeyama, Shotaro Sakisaka
Feb 13, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ewa WunschPiotr Milkiewicz
Jun 29, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Mayako MoriiHaruki Senoo
Jul 23, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ahmad SharanekAndre Guillouzo
Mar 1, 2016·The Journal of Steroid Biochemistry and Molecular Biology·A Sánchez-GuijoS A Wudy
Apr 18, 2015·BMC Pregnancy and Childbirth·Paul Anthony DawsonHarold David McIntyre
Oct 2, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yihong LuLaura K Schnackenberg
Jan 25, 2014·Marine Pollution Bulletin·Sergio Manzetti, Rossella Ghisi
Jan 7, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Wim F P M Van den HofJos C S Kleinjans
Oct 26, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sai Praneeth R BathenaYazen Alnouti
Oct 26, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sai Praneeth R BathenaYazen Alnouti
Jun 2, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jieying GaoMin Ding
Jul 6, 2014·Journal of Proteome Research·Alesia WalkerPhilippe Schmitt-Kopplin
Mar 22, 2014·Chemical Research in Toxicology·Sergio ManzettiDavid van der Spoel
Aug 27, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ke LiWeiming Li

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