PMID: 15374163Jul 1, 1996Paper

Bile acid synthesis in young and old rats

Archives of Gerontology and Geriatrics
T SatohN Takeuchi

Abstract

Bile acid synthesis from orally administered (14)C-cholesterol or from (14)C-mevalonic acid administered intravenously were examined in male and female 2-, 12- and 24-month-old rats. About 5-9% of the '4C-cholesterol administered was recovered as bile acids from the small intestine 3 days after administration. The value in the case of (14)C-mevalonic acid was about 1/10 that of (14)C-cholesterol. Major bile acids were cholic acid and beta-muricholic acid, and the formation ratio of cholic acid increased in aged rats, although no further difference was found between 12- and 24-month-old animals of either sex. Male rats formed more beta-muricholic acid than females at all ages examined. In addition, no significant difference was found in the bile acid composition between both precursors, (14)C-cholesterol and (14)C-mevalonic acid.

References

Jan 1, 1979·Experimental Gerontology·D Hollander, D Morgan
Aug 1, 1979·Japanese Journal of Pharmacology·K UchidaN Takeuchi
Jan 1, 1978·Lipids·K UchidaN Takeuchi
Apr 1, 1977·Japanese Journal of Pharmacology·K UchidaY Yamamura
Aug 1, 1976·Lipids·J A StoryD Kritchevsky
Aug 1, 1985·The New England Journal of Medicine·K EinarssonB Angelin
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Jan 1, 1994·Journal of Atherosclerosis and Thrombosis·K UchidaN Takeuchi
Jan 1, 1990·Archives of Gerontology and Geriatrics·K UchidaN Takeuchi

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Citations

Apr 1, 1997·Lipids·K UchidaN Takeuchi
Oct 12, 2010·Tissue Engineering. Part a·Christopher J DetzelPadmavathy Rajagopalan
Sep 6, 2008·Journal of Lipid Research·Masahito HagioSatoshi Ishizuka

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