Bile Acids Activated Receptors Regulate Innate Immunity

Frontiers in Immunology
Stefano FiorucciEleonora Distrutti

Abstract

Once known exclusively for their role in nutrients absorption, primary bile acids, chenodeoxycholic and cholic acid, and secondary bile acids, deoxycholic and lithocholic acid, are signaling molecules, generated from cholesterol breakdown by the interaction of the host and intestinal microbiota, acting on several receptors including the G protein-coupled bile acid receptor 1 (GPBAR1 or Takeda G-protein receptor 5) and the Farnesoid-X-Receptor (FXR). Both receptors are placed at the interface of the host immune system with the intestinal microbiota and are highly represented in cells of innate immunity such as intestinal and liver macrophages, dendritic cells and natural killer T cells. Here, we review how GPBAR1 and FXR modulate the intestinal and liver innate immune system and contribute to the maintenance of a tolerogenic phenotype in entero-hepatic tissues, and how regulation of innate immunity might help to explain beneficial effects exerted by GPBAR1 and FXR ligands in immune and metabolic disorders.

References

Aug 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M YoshikawaS Ishizaka
Jun 1, 1990·Journal of Leukocyte Biology·L J Dahm, R A Roth
Mar 23, 2000·Journal of Hepatology·R PouponR E Poupon
Oct 7, 2000·Journal of Gastroenterology and Hepatology·M OhtsukaN Nakajima
Jun 2, 2001·The Journal of Biological Chemistry·M AnanthanarayananF J Suchy
Jun 14, 2002·Developmental Cell·Li WangDavid D Moore
Aug 9, 2002·Journal of Medicinal Chemistry·Roberto PellicciariTimothy M Willson
Nov 7, 2002·Biochemical and Biophysical Research Communications·Takaharu MaruyamaKenichi Tanaka
Jan 14, 2003·The Journal of Biological Chemistry·Yuji KawamataMasahiko Fujino
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jaspreet S GujralHartmut Jaeschke
Oct 18, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jaspreet S GujralHartmut Jaeschke
Jan 13, 2005·The Journal of Pharmacology and Experimental Therapeutics·Stefano FiorucciAntonio Morelli
Nov 22, 2005·Journal of Lipid Research·Jason M RidlonPhillip B Hylemon
Dec 1, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nazzareno BallatoriNa Li
May 10, 2006·The Journal of Biological Chemistry·Diana JungUrs A Meyer
May 27, 2006·The Biochemical Journal·Galya VassilevaEric L Gustafson
Jun 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joshua I BleierRonald P DeMatteo
Feb 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Verena KeitelRalf Kubitz
Apr 25, 2008·Autoimmunity·Amr H Sawalha
Sep 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Brian V JonesJulian R Marchesi
Dec 26, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Girdhari LalJonathan S Bromberg
Feb 3, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ana LleoM Eric Gershwin
Apr 7, 2009·Journal of Lipid Research·John Y L Chiang
Apr 11, 2009·World Journal of Gastroenterology : WJG·Maria-J Perez, Oscar Briz
May 7, 2009·Journal of Lipid Research·Joana D AmaralCecília M P Rodrigues
Oct 30, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Piero VavassoriStefano Fiorucci
Nov 3, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrea MencarelliStefano Fiorucci
Jul 21, 2010·Current Molecular Medicine·S FiorucciF Baldelli
Dec 15, 2010·Journal of Hepatology·Thijs W H PolsKristina Schoonjans
Jan 29, 2011·Gut·Manon E Wildenberg, Gijs R van den Brink
Sep 8, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ana LleoM Eric Gershwin
Dec 14, 2011·Cell Metabolism·Thijs W H PolsKristina Schoonjans
Jun 16, 2012·Nature·UNKNOWN Human Microbiome Project Consortium
Aug 14, 2012·Journal of Hepatology·Emina HalilbasicMichael Trauner
Sep 11, 2012·Nature Genetics·Jimmy Z LiuUNKNOWN Wellcome Trust Case Control Consortium 3
Sep 14, 2012·Nature·Catherine A LozuponeRob Knight

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Citations

Jul 11, 2019·International Journal of Cancer. Journal International Du Cancer·Tianyu LiuHailong Cao
Nov 2, 2019·Genome Biology and Evolution·Bogdan M KirilenkoMichael Hiller
Dec 5, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Andreacarola UrsoJose F Perez-Zoghbi
Jan 22, 2020·Journal of Periodontology·Reza TalebianReinhard Gruber
Apr 7, 2020·The American Journal of Gastroenterology·Ayesha ShahGerald Holtmann
Sep 29, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mary FrancisDebra L Laskin
May 5, 2020·Frontiers in Immunology·Zhao Shan, Cynthia Ju
Feb 16, 2020·Critical Care : the Official Journal of the Critical Care Forum·Gustav van NiekerkAnna-Mart Engelbrecht
Mar 28, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michele BiagioliStefano Fiorucci
Jan 18, 2020·Metabolomics : Official Journal of the Metabolomic Society·Yu Ra LeeBong Chul Chung
Sep 2, 2020·Cells·Prashanta SilwalEun-Kyeong Jo
Apr 17, 2020·Frontiers in Immunology·José M CarballidoMichael Kammüller
Aug 28, 2020·International Journal of Molecular Sciences·Teerasak WongwanSunhapas Soodvilai
Oct 1, 2020·Molecular Nutrition & Food Research·Jonas PoppeKristin Verbeke
Dec 9, 2020·Digestive Diseases and Sciences·Stefano FiorucciMichele Biagioli
Jul 22, 2019·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Adriana CarinoStefano Fiorucci
Jun 22, 2019·Cellular and Molecular Gastroenterology and Hepatology·Michele BiagioliStefano Fiorucci
Jan 26, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Qichao HuYanling Zhao
Dec 29, 2020·International Immunology·Bernard C LoRoberta Caruso
Jan 20, 2021·Clinical and Translational Gastroenterology·Thanika KetpueakNipon Chattipakorn
Oct 29, 2020·Cellular & Molecular Immunology·Andrea Kristina HorstGisa Tiegs
Jan 1, 2021·Journal of Immunology Research·Jun-Bin YanBei-Hui He
Dec 29, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Adriana CarinoStefano Fiorucci
Oct 28, 2020·International Journal of Molecular Sciences·Spencer N WrenDonato F Romagnolo
Jan 21, 2021·Metabolites·Santosh LamichhaneMatej Orešič
Feb 3, 2021·Proceedings of the National Academy of Sciences of the United States of America·Matthew H FoleyCasey M Theriot
Feb 13, 2021·International Journal of Molecular Sciences·Niklas Grüner, Jochen Mattner
Feb 6, 2021·Cellular and Molecular Gastroenterology and Hepatology·Julia LeonhardtRegine Heller
Feb 27, 2020·Cell Host & Microbe·Sidhartha R SinhaAida Habtezion
Apr 20, 2019·The Journal of Steroid Biochemistry and Molecular Biology·Sayyed Hamed Shahoei, Erik R Nelson

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Methods Mentioned

BETA
amidation
sumoylation
deamidation
ubiquitination

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