Bile Acids and Cancer: Direct and Environmental-Dependent Effects

Annals of Hepatology
Agostino Di CiaulaPiero Portincasa

Abstract

Bile acids (BAs) regulate the absorption of fat-soluble vitamins, cholesterol and lipids but have also a key role as singalling molecules and in the modulation of epithelial cell proliferation, gene expression and metabolism. These homeostatic pathways, when disrupted, are able to promote local inflammation, systemic metabolic disorders and, ultimately, cancer. The effect of hydrophobic BAs, in particular, can be linked with cancer in several digestive (mainly oesophagus, stomach, liver, pancreas, biliary tract, colon) and extra-digestive organs (i.e. prostate, breast) through a complex series of mechanisms including direct oxidative stress with DNA damage, apoptosis, epigenetic factors regulating gene expression, reduced/increased expression of nuclear receptors (mainly farnesoid X receptor, FXR) and altered composition of gut microbiota, also acting as a common interface between environmental factors (including diet, lifestyle, exposure to toxics) and the molecular events promoting cancerogenesis. Primary prevention strategies (i.e. changes in dietary habits and lifestyle, reduced exposure to environmental toxics) mainly able to modulate gut microbiota and the epigenome, and the therapeutic use of hydrophilic BAs to counterba...Continue Reading

Citations

Dec 27, 2018·Current Opinion in Gastroenterology·Eamonn M M Quigley
Feb 16, 2019·The Journal of Critical Care Medicine·Piero PortincasaDavid Q-H Wang
May 6, 2020·Veterinary World·Heny ArwatiWilly Sandhika
Aug 23, 2020·Journal of Clinical Medicine·Agostino Di CiaulaPiero Portincasa
Oct 23, 2019·Frontiers in Cell and Developmental Biology·Bridget MartinezDavid Mascareñas
Oct 30, 2020·Cells·Jesús Cosín-RogerSara Calatayud
Aug 31, 2020·IScience·Qian ZhangGuiyu Wang
Dec 10, 2020·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Jin-Nan WuJin-Liang Chen
Dec 31, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Luisa NavacchiaDaniela Perrone
Feb 14, 2021·International Journal of Molecular Sciences·Maria Chiara di GregorioLuciano Galantini

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