PMID: 1193418Nov 1, 1975Paper

Bile acids and colonic motility in the rabbit and the human

Gut
W O KirwanM A Eastwood

Abstract

Colonic motor activity was initiated by infusions of bile salts into the caecum or rectum of the anaesthetized rabbit. Primary bile acids were examined proximally and distally in the colon and elicited marked motor responses. Sinc dihydroxy bile acids are known to be potent inhibitors of electrolyte and water absorption in the colon, the secondary bile acid deoxycholic acid, the dihydroxyl compound most related to cholic acid which is the main bile acid in the rabbit, was examined distally and was also active, but to a lesser extent than cholic acid conjugates in this species. In man, a relationship was found between the faecal bile acid excretion and colonic motility: the introduction of bile acids directly into the human sigmoid colon and rectum also stimulated colonic motility. In man, the dihydroxy compound chenodeoxycholic acid was slightly more active than conjugates of cholic acid.

References

Aug 1, 1968·The Journal of Clinical Endocrinology and Metabolism·T S DanowskiJ H Sunder
May 1, 1973·Gut·W D MitchellD B Horn
Aug 1, 1971·The Journal of Clinical Investigation·H S MekjianA F Hofmann
Jan 1, 1972·Scandinavian Journal of Gastroenterology·W D Mitchell, M A Eastwood
Aug 1, 1971·The American Journal of Digestive Diseases·A N SmithS Clarke

❮ Previous
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Citations

Jan 1, 1985·Digestive Diseases and Sciences·S LevinsonW J Snape
Sep 20, 2005·Current Gastroenterology Reports·Bruce W Robb, Jeffrey B Matthews
Sep 5, 2012·Nature Reviews. Gastroenterology & Hepatology·Stacy MeneesWilliam D Chey
Nov 14, 2012·Nature Reviews. Gastroenterology & Hepatology·Magnus Halland, Nicholas J Talley
Aug 1, 1993·The Proceedings of the Nutrition Society·C Edwards
Jan 1, 1990·Critical Reviews in Food Science and Nutrition·J W AndersonS E Whitis
Mar 1, 1989·Gut·C A EdwardsN W Read
Apr 1, 1982·The Journal of Clinical Investigation·S J ShiffW J Snape
May 7, 2009·World Journal of Gastroenterology : WJG·Victoria Geenes, Catherine Williamson
Mar 26, 2010·Scandinavian Journal of Gastroenterology·Antal BajorHasse Abrahamsson
Apr 1, 1987·Scandinavian Journal of Gastroenterology·M Vuoristo, T A Miettinen
Sep 1, 1986·Scandinavian Journal of Gastroenterology·I BosaeusH Andersson
Oct 25, 2011·Expert Review of Gastroenterology & Hepatology·Monthira Maneerattanaporn, William D Chey
Jan 15, 2014·Expert Review of Gastroenterology & Hepatology·Michael Camilleri
Feb 1, 2014·Expert Opinion on Biological Therapy·Mitchell L JonesSatya Prakash
Nov 20, 2012·Molecular and Cellular Endocrinology·Shadi Abu-HayyehCatherine Williamson
Feb 22, 2011·Gastroenterology Clinics of North America·Monthira ManeerattanapornWilliam D Chey
Oct 9, 2015·Current Gastroenterology Reports·Akhilesh WadhwaMadhusudan Grover
Nov 3, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Suwebatu T Odunsi-ShiyanbadeAlan R Zinsmeister
Feb 24, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H DubocJ M Sabaté
Apr 19, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Christopher S Reigstad, Purna C Kashyap
Sep 30, 2009·Alimentary Pharmacology & Therapeutics·M Camilleri
Jun 18, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S J Keely
Mar 20, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D P PooleC U Corvera
Nov 1, 1983·Acta paediatrica Scandinavica·M BerantS Yurman
Mar 3, 2015·Alimentary Pharmacology & Therapeutics·D Le PluartC Julia
Sep 1, 1993·Journal of the American Geriatrics Society·R C Deckmann, L J Cheskin
May 5, 2016·Gastroenterology·Giovanni BarbaraErwin G Zoetendal
Nov 20, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Cédric PelemanAlan R Zinsmeister
Nov 1, 1979·The British Journal of Surgery·M FlynnI Taylor
May 31, 2017·Journal of Neurogastroenterology and Motility·Nam Hee KimYeun-Ho Joung
Apr 20, 2004·The American Journal of Gastroenterology·Riadh SadikPer-Ove Stotzer
Jan 18, 2018·The Journal of Experimental Medicine·Hagit ShapiroEran Elinav
Sep 12, 2018·Expert Review of Gastroenterology & Hepatology·Victor ChedidMichael Camilleri
Nov 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P MarteauR Poupon

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