Bile acids and male fertility: From mouse to human?

Molecular Aspects of Medicine
Lauriane SèdesDavid H Volle

Abstract

Next to their involvement in digestion, bile acids have been defined as signaling molecules. They have been demonstrated to control many physiological functions among which lipid homeostasis, glucose and energy metabolisms. Bile acids are ligands of several receptors and multiple studies using transgenic mouse models defined the major roles of their respective nuclear and membrane receptors namely the Farnesoid-X-Receptor (FXRα) and the G-protein-coupled bile acid receptor 1(GPBAR1; TGR5). Here we review the reports highlighting the impacts of bile acids on testicular physiology and on male reproductive functions. The studies on mouse models open perspectives to better understand the deleterious effects of bile acids on testicular pathophysiologies and fertility disorders. Additional studies are needed to corroborate these correlations in humans.

Citations

Jun 21, 2018·Reproduction : the Official Journal of the Society for the Study of Fertility·R MalivindiS Aquila
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Agostino Di CiaulaPiero Portincasa
Aug 14, 2019·Cellular and Molecular Life Sciences : CMLS·Manon GarciaDavid H Volle
Aug 4, 2018·Frontiers in Endocrinology·Lauriane SèdesDavid H Volle
Aug 31, 2019·The Journal of Steroid Biochemistry and Molecular Biology·Hélène HolotaDavid H Volle
May 15, 2021·Gut·Emmanuelle MartinotDavid H Volle

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