Bile acids for viral hepatitis

The Cochrane Database of Systematic Reviews
W ChenC Gluud

Abstract

The viral hepatitides are common causes of liver diseases globally. Trials have assessed bile acids for patients with viral hepatitis, but no consensus was reached regarding their usefulness. To assess the beneficial and harmful effects of bile acids for viral hepatitis. Searches were performed of the trial registers of The Cochrane Hepato-Biliary Group (September 2002), The Cochrane Library (Issue 2, 2002), MEDLINE (September 2002), EMBASE (September 2002), and The Chinese Biomedical Database (April 2001). Randomised clinical trials comparing any dose or duration of bile acids versus placebo or no intervention for viral hepatitis were included, irrespective of language, publication status, or blinding. Two reviewers extracted the data independently. The methodological quality of the trials was evaluated with respect to generation of the allocation sequence, allocation concealment, double blinding, and follow-up. The outcomes were presented as relative risks (RR) or weighted mean differences (WMD) with 95% confidence intervals (CI). We identified 27 randomised trials of bile acids for hepatitis B or C; none were of high methodological quality. In one trial, ursodeoxycholic acid (UDCA) versus placebo for acute hepatitis B signif...Continue Reading

Related Concepts

Bile Acid Measurement
Histology Procedure
Hepatitis
Cirrhosis
Hepatitis A
Hepatitis B, Chronic
Hepatitis C, Chronic
Adverse Event
Liver Diseases
Hepatitis A Vaccine, Inactivated

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