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Bile acids. XLVII. 12alpha-Hydroxylation of precursors of allo bile acids by rabbit liver microsomes

Biochimica Et Biophysica Acta

Nov 21, 1975

Salwa Ali, Winston Howard Elliott

PMID: 65

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Abstract

Rabbit liver microsomal preparations fortified with 0.1 mM NADPH effectively promote hydroxylation of [3beta-3H]- or [24-14C]allochenodeoxycholic acid or [5alpha,6alpha-3H2]5alpha-cholestane-3alpha,7alpha-diol to their respective 12alpha-hydroxyl derivatives in yields of about 25 or 65%...read more

Mentioned in this Paper

Enzyme Inhibitors [MoA]
cholesteryl sulfate, 3H-labeled, (3beta)-isomer
Oxidation-Reduction
NADP
Cholestanes
Acids
Enzyme Inhibitor Drugs
Enzyme Inhibitor Activity
Allopurinol
Hydroxyl group
Paper Details
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  • Bile acids. XLVII. 12alpha-Hydroxylation of precursors of allo bile acids by rabbit liver microsomes

    Biochimica Et Biophysica Acta

    Nov 21, 1975

    Salwa Ali, Winston Howard Elliott

    PMID: 65

    DOI:

    Abstract

    Rabbit liver microsomal preparations fortified with 0.1 mM NADPH effectively promote hydroxylation of [3beta-3H]- or [24-14C]allochenodeoxycholic acid or [5alpha,6alpha-3H2]5alpha-cholestane-3alpha,7alpha-diol to their respective 12alpha-hydroxyl derivatives in yields of about 25 or 65%...read more

    Mentioned in this Paper

    Enzyme Inhibitors [MoA]
    cholesteryl sulfate, 3H-labeled, (3beta)-isomer
    Oxidation-Reduction
    NADP
    Cholestanes

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