Bile salt-reinforced alginate-chitosan beads

Pharmaceutical Development and Technology
Sevgi Takka, Aybige Gürel Cali

Abstract

A polymeric delayed release protein delivery system was investigated with albumin as the model drug. The polysaccharide chitosan was reacted with sodium alginate in the presence of calcium chloride to form beads with a polyelectrolyte. In this study, attempts were made to extend albumin release in the phosphate buffer at pH 6.8 from the alginate-chitosan beads by reinforcing the matrix with bile salts. Sodium taurocholate was able to prevent albumin release at pH 1.2, protecting the protein from the acidic environment and extending the total albumin release at pH 6.8. This effect was explained by an interaction between the permanent negatively charged sulfonic acid of sodium taurocholate with the amino groups of chitosan. Mild formulation conditions, high bovine serum albumin (BSA) entrapment efficiency, and resistance to gastrointestinal release seem to be synergic and promising factors toward the development of an oral protein delivery form.

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Citations

Jul 12, 2014·Artificial Cells, Nanomedicine, and Biotechnology·Armin MooranianHani Al-Salami
May 7, 2014·Pharmaceutical Development and Technology·Armin MooranianHani Al-Salami
Nov 2, 2016·ACS Applied Materials & Interfaces·Kristian J TangsoBen J Boyd
Aug 31, 2016·Journal of Microencapsulation·Armin MooranianHani Al-Salami

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