PMID: 3756192Sep 12, 1986Paper

Bile salt-stimulated lipase in non-primate milk: longitudinal variation and lipase characteristics in cat and dog milk

Biochimica Et Biophysica Acta
L M FreedP Hamosh

Abstract

We report the presence of bile salt-stimulated lipase in milk collected from dog and cat. This enzyme has previously been found only in the milk of human and gorilla. Bile salt-stimulated lipase activity in individual dog milk specimens (range: 4.8-107.4 U/ml; 1 U = 1 mumol [3H]oleic acid released/min) was similar, while that in cat milk specimens (range: 2.2-16.9 U/ml) was lower than in human milk (range: 10-80 U/ml). Longitudinal patterns for bile salt-stimulated lipase activity differed depending upon the enzyme source: in dog milk, lipase activity was lowest in colostrum, while in cat milk, lipase activity was highest in colostrum and decreased at mid-lactation. In human milk, bile salt-stimulated lipase activity levels remain fairly constant throughout the first 3 months of lactation. Dog, cat and human milk bile salt-stimulated lipase activity had a neutral-to-alkaline pH optimum of 7.3-8.5, was stable at low pH (above 3.0 for at least 1 h), and was inhibited 95-100% by eserine (at concentrations greater than 0.6 mM). The lipase in the milk of the three species studied had an absolute requirement for primary bile salts (tauro- and glycocholate), and was inhibited by secondary bile salts (tauro- and glycodeoxycholate). The...Continue Reading

References

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Aug 22, 1985·Biochimica Et Biophysica Acta·S J DeNigrisP Hamosh
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Citations

Jan 14, 2003·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Jörg M SteinerDavid A Williams
Jan 15, 1997·European Journal of Biochemistry·E MasM O Sadoulet
May 21, 2003·American Journal of Veterinary Research·Randal K BuddingtonJillian B Donahoo
Sep 5, 2018·The British Journal of Nutrition·Chhinder P SodhiDavid J Hackam
Apr 1, 1989·Journal of the American College of Nutrition·L M FreedM Hamosh
Jan 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·M HamoshP Hamosh
Sep 14, 1999·The American Journal of Physiology·P N HowlesD Y Hui
Aug 22, 2001·Biochimica Et Biophysica Acta·D Lombardo
Feb 10, 1993·Biochimica Et Biophysica Acta·C S Wang, J A Hartsuck
Nov 1, 1987·Advances in Colloid and Interface Science·C J O'Connor, B M Sutton

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