PMID: 7467404Mar 1, 1980

Biliary and urinary excretion of [14C]warfarin in rabbits

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
L T Wong, G Solomonraj


1. The biliary and urinary excretion of racemic [14C]warfarin (1 mg/kg) was studied in male rabbits. 2. In the first 6 h after dosing (i.v.), of the administered radioactivity was excreted warfarin and its hydroxylated metabolites. 3. Four days after oral dosing, about 90% of the administered radioactivity was recovered in the urine. The major urinary metabolites were identified as warfarin alcohols, unchanged warfarin, 6-, 7-, and 4'-hydroxywarfarin; their structures were unequivocally confirmed by g.l.c.-mass spectrometric analysis. 4. In the rabbit, the bile was only a minor excretory route for warfarin, and only polar and bulky conjugates of the drug were eliminated by this pathway.


Apr 1, 1978·The Journal of Pharmacy and Pharmacology·L T WongB H Thomas
Nov 1, 1974·Journal of Pharmaceutical Sciences·K K MidhaJ K Cooper
Jun 1, 1974·Toxicology and Applied Pharmacology·B B ColdwellB H Thomas
Nov 1, 1970·Journal of Medicinal Chemistry·W F TragerW A Garland


Mar 1, 1981·Toxicology Letters·J K MalikF Korte
Jan 1, 1987·Reviews on Drug Metabolism and Drug Interactions·F A SutcliffeG G Gibson
Aug 1, 1987·The Journal of Pharmacy and Pharmacology·H H Thijssen, L G Baars
Jan 1, 1989·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·K R HuckleP A Warburton

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