PMID: 592078Dec 1, 1977

Biliary Atresia: histopathologic observations and reflections upon its natural history

Journal of Pediatric Surgery
A H BillG L Foster

Abstract

Operative liver biopsies and specimens of the extrahepatic ducts and porta hepatis have been studied in 12 cases of biliary atresia. In all cases, the liver showed giant cell transformation and inflammation with mononuclear cells and neutrophils. Most had other features of neonatal hepatitis, including necrosis of hepatocytes. In the intrahepatic bile ducts of all cases but one, the hepatic ducts and glands at the porta hepatis, and in the extrahepatic ducts where epithelium remained, there was degeneration of the epithelium and intramural inflammation. In the ducts at the porta hepatis and in 6 of 8 extrahepatic ducts where epithelium remained, there was extensive mural fibrosis compromising the diameter of the duct lumens. Three cases showed the inflammatory changes distal to sites of closure of the extrahepatic ducts. These findings demonstrate that in biliary atresia, hepatitis, intrahepatic cholangitis, and sclerosing cholangitis of the extrahepatic ducts all interact to produce acquired obstruction to bile flow.

References

Apr 1, 1975·The Tohoku Journal of Experimental Medicine·T Chiba, M Kasai
Jan 23, 1975·The New England Journal of Medicine·J D Johnson
Oct 1, 1969·The Tohoku Journal of Experimental Medicine·R OiT Takahashi
Mar 1, 1957·The Journal of Pediatrics·M G PETERMAN
Jul 1, 1962·The Journal of Pediatrics·R L BRENT
Mar 1, 1964·American Journal of Surgery·T M HOLDER

Citations

Jun 1, 1981·Digestive Diseases and Sciences·J Perrault
Sep 1, 1978·World Journal of Surgery·J E Haas
Sep 17, 2009·Journal of Clinical Immunology·Hung-Chang LeeYann-Jinn Lee
Dec 1, 1984·The Journal of Pediatrics·J H GlaserR Morecki
Jun 27, 2003·Journal of Pediatric Gastroenterology and Nutrition·Ronald J SokolFrederick M Karrer
May 7, 2004·Pediatric Research·Cara L MackStephen D Miller
Apr 9, 2005·Pediatric Research·Cara L Mack, Ronald J Sokol
Jun 30, 2012·Archives of Pathology & Laboratory Medicine·Roger Klein MoreiraSteven J Lobritto
Jan 14, 2011·Annual Review of Medicine·Kazuhiko Bessho, Jorge A Bezerra
Feb 28, 2002·Radiology·Karen I NortonBenjamin L Shneider
Jun 18, 2009·Seminars in Immunopathology·Giorgina Mieli-Vergani, Diego Vergani
Sep 30, 2010·Gastroenterology·Carlo SelmiGiorgina Mieli-Vergani
Apr 20, 2010·Pathology, Research and Practice·Sheelah Changho, Atif A Ahmed
Jul 22, 2008·Journal of Pediatric Surgery·Jens StahlschmidtPatricia McClean
Dec 1, 1979·Journal of Pediatric Surgery·K KimuraS Hashimoto
Apr 4, 2006·The Surgical Clinics of North America·Max R Langham, Kristin L Mekeel
Sep 24, 2005·Pediatric Transplantation·Jorge A Bezerra
Mar 25, 2005·Pediatric Transplantation·Robert H Squires
Dec 1, 1981·American Journal of Surgery·D C HitchE I Smith
May 27, 2015·Nature Reviews. Gastroenterology & Hepatology·Akihiro AsaiJorge A Bezerra
Oct 18, 2005·Seminars in Pediatric Surgery·Luis AlvarezManuel López-Santamaría
Jul 29, 2010·Journal of the History of Biology·Trevor Pearce
Apr 25, 2019·American Journal of Human Biology : the Official Journal of the Human Biology Council·Gustavo M TavaresNelson J R Fagundes

Related Concepts

Bile Duct Structure
Biliary Tract Structure
Biliary Tract Diseases
Cholangitis
Hepatitis
Liver

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.