Biliary atresia screening in Shenzhen: implementation and achievements

Archives of Disease in Childhood
Jiachen ZhengLihui Zhang

Abstract

To elaborate on the implementation and achievements of a biliary atresia (BA) screening programme in Shenzhen. In 2015, we partnered with the government in Shenzhen and attached the stool colour card (SCC) to the health handbook for mothers and children. These handbooks have been distributed through official channels to every pregnant woman in Shenzhen since 1 January 2015. A total of 118 patients diagnosed with BA at Shenzhen Children's Hospital were enrolled and divided into two cohorts based on their date of diagnosis: cohort A before and cohort B after introduction of screening. The cohorts were compared to evaluate differences in age at diagnosis, jaundice-free rate, 2-year native liver survival rate and so on. After the implementation of the screening programme, the age at diagnosis decreased from 81±12 to 56±15 days old (p<0.05), the incidence of postoperative complications decreased from 58.8% to 52.6% (p<0.05), the jaundice-free rate increased from 47.1% to 54.4% (p<0.05), and the 2-year native liver survival rate increased from 44.4% to 52.6% (p<0.05). The percentage of patients who underwent surgery increased from 68.0% to 83.8% (p<0.05). In Shenzhen, our screening programme led to earlier diagnoses and better progno...Continue Reading

References

Apr 9, 1994·Lancet·A Matsui, T Ishikawa
Apr 6, 2006·Pediatrics·Shan-Ming ChenUNKNOWN Taiwan Infant Stool Color Card Study Group
Apr 1, 2008·Journal of Pediatric Gastroenterology and Nutrition·Barbara E WildhaberChristophe Chardot
Dec 9, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tien-Hau LienUNKNOWN Taiwan Infant Stool Color Card Study Group
Dec 2, 2015·Pediatrics·Kasper S WangUNKNOWN CHILDHOOD LIVER DISEASE RESEARCH NETWORK
Dec 18, 2015·World Journal of Gastroenterology : WJG·Jen-Shyang LinWai-Tao Chan
Jun 28, 2016·Journal of Autoimmunity·Bhanumathi Lakshminarayanan, Mark Davenport
Oct 7, 2017·Pediatric Surgery International·Cat GoodhueKasper S Wang
Mar 24, 2018·Journal of Pediatric Gastroenterology and Nutrition·Jessica P WoolfsonJean Paul Collet

❮ Previous
Next ❯

Citations

Jun 27, 2020·Archives of Disease in Childhood·Patrick James McKiernan
Mar 6, 2021·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Mortada H El-ShabrawiAhmed E Farag
Aug 29, 2021·Indian Journal of Pediatrics·Padma Sagarika KarriNishad Plakkal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.