Biliary cystadenomas: hormone receptor expression and clinical management.

Digestive Diseases and Sciences
Jason A DanielsTimothy D Sielaff

Abstract

Biliary cystadenomas with mesenchymal stroma are neoplasms whose growth may be hormone sensitive. This study profiled the immunohistochemistry of these lesions to clarify the pathophysiology and define clinical management. Twelve patients with biliary cystadenomas were identified. Tissue was tested with a panel of probes including estrogen and progesterone receptors and compared to pancreatic and ovarian cystadenomas. Epithelial ER, PR, CD117, or SMA expression was negative in all three tumors. Epithelial CD10 expression was seen in 60% biliary, 75% pancreatic, and 0% ovarian tumors. Biliary cystadenoma stromal expression was ER+ (70%), PR+ (60%), CD10+ (40%), and c-kit+ (0%). Symptoms were seen in 92% patients. Percutaneous sclerotherapy and incomplete resection were associated with recurrence. Enucleation was the least morbid surgical technique. A role for hormonally mediated growth of biliary cystadenomas occurring through the stroma, rather than the epithelium, is suggested. Management remains complete surgical resection.

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Citations

Apr 23, 2008·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Andrew McCagueKeith O'Malley
Sep 21, 2013·Journal of the American College of Surgeons·Kevin C SoaresTimothy M Pawlik
Oct 31, 2015·Digestive Diseases and Sciences·Monica M DuaBrendan C Visser
Jul 5, 2011·Cirugía española·José Manuel RamiaJorge García-Parreño
Apr 26, 2007·Virchows Archiv : an International Journal of Pathology·Hala M Abdul-AlZachary D Goodman
Sep 29, 2015·Khirurgiia·P V UsiakiĭD V Kalinin
Jun 27, 2019·BMC Gastroenterology·Côme TholomierJean-Sebastien Pelletier
Sep 11, 2021·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Steven M Strasberg, William C Chapman

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