PMID: 3761168Jul 1, 1986Paper

Biliary excretion and enterohepatic cycling of glycyrrhizin in rats

Journal of Pharmaceutical Sciences
T IchikawaM Hanano

Abstract

The enterohepatic cycling of glycyrrhizin was examined using rats with and without biliary fistulization. The plasma decay in the control rats without fistulization following an iv dose of 100 mg/kg of glycyrrhizin, was generally biphasic. However, secondary peaks were observed in all rats in the elimination phase, i.e., 0.5 to 12 h following dosing. The plasma concentrations in the rats with biliary fistulization administered the same dose showed a biexponential decline. The AUC and CLtot were significantly higher and lower in the control rats, respectively. The biliary excretion was 80.6 +/- 9.9% of the administered dose, and intestinal absorption was confirmed by using the bile collected after iv dosing. From these results, we concluded that glycyrrhizin was predominantly secreted from the liver into the bile, and that the secondary peaks in the elimination phase, the higher AUC, and the lower CLtot in the control rats were due to the effects of enterohepatic recycling of glycyrrhizin. Furthermore, the transport of the drug from the liver to the bile appears to be a saturable process.

References

Mar 15, 1980·Experientia·R PompeiB Loddo
Aug 1, 1982·Journal of Pharmacokinetics and Biopharmaceutics·F L TseJ Skinn
Sep 1, 1957·The Journal of Experimental Medicine·S D KRAUS

❮ Previous
Next ❯

Citations

Jan 28, 2004·European Journal of Drug Metabolism and Pharmacokinetics·Qin HuGang Hu
Oct 10, 2008·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Nobuaki NakataKunio Takaoka
Oct 3, 2003·International Journal of Pharmaceutics·Kazuhiro SasakiKozo Takayama
Jul 1, 1991·The Journal of Pharmacy and Pharmacology·H Y Yu, Y Z Shen
Mar 19, 2011·Biological & Pharmaceutical Bulletin·Kenjiro KogaKanji Takada
Jul 3, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kenjiro KogaKanji Takada
Nov 1, 2013·Drug Design, Development and Therapy·Kenjiro KogaNobuji Yoshikawa
May 21, 2010·Clinical Pharmacokinetics·Neal M DaviesJaime A Yáñez
Apr 1, 2015·Drug Metabolism Reviews·Xinchi FengFeng Qiu
Sep 1, 1992·Journal of Pharmaceutical Sciences·T H TsaiC F Chen
Nov 3, 2015·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Qingfeng LiuHui Zhao
Nov 13, 2009·Biopharmaceutics & Drug Disposition·Yue ChenHua Gao
Jan 13, 2010·Forensic Science International : Synergy·M E AlbermannB Madea
Jun 13, 2008·Biopharmaceutics & Drug Disposition·Kenjiro KogaKanji Takada
Apr 18, 2012·Biopharmaceutics & Drug Disposition·Ruijuan XuJiping Wang
Apr 26, 2005·International Journal of Pharmaceutics·Yan WuShoukuan Fu
May 1, 1997·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·G Cantelli-FortiN M Trieff
Oct 1, 1993·Biopharmaceutics & Drug Disposition·N TanakaT Iga

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.