PMID: 11325544Apr 28, 2001Paper

Biliary excretion of polystyrene microspheres depends on the type of receptor-mediated uptake in rat liver

Biochimica Et Biophysica Acta
Kentaro FurumotoT Kimura

Abstract

Hepatic uptake and biliary excretion of fluorescein isothiocyanate-labeled polystyrene microspheres with a particle size of 50 nm (MS-50) were studied in rats. Liver perfusion studies revealed that not only apo-E-mediated but also asialoglycoprotein receptor-mediated uptake is involved in the mechanism of the serum protein-dependent uptake of MS-50 in the liver. The uptake of MS-50 mediated by apo-E contributes more to the total uptake of MS-50 by the hepatocytes than that via asialoglycoprotein receptor in the presence of serum in the perfusate. Furthermore, it was found that MS-50 is substantially excreted into the bile by transcytosis. The extent of exocytosis of MS-50 taken up by the hepatocytes was much higher after MS-50 was endocytosed via asialoglycoprotein receptor than after taken up via the process mediated by apo-E. On the basis of these results, a possible regulation of the intracellular sorting of ligands, depending on the receptor-mediated uptake mechanism, was inferred.

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Citations

Jan 31, 2008·Proceedings of the National Academy of Sciences of the United States of America·Zhuang LiuHongjie Dai
Jun 27, 2013·Nanomedicine·Isaac M AdjeiVinod Labhasetwar
Apr 6, 2013·Therapeutic Delivery·Jamie L BetkerThomas J Anchordoquy
May 12, 2012·Archives of Toxicology·Robert LandsiedelFranz Oesch
Oct 18, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Nicolas Bertrand, Jean-Christophe Leroux
Sep 18, 2007·Regulatory Toxicology and Pharmacology : RTP·Werner I HagensAdriënne J A M Sips
Jan 28, 2014·Photochemistry and Photobiology·Michal Pellach, Shlomo Margel
Aug 8, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jamie L BetkerThomas J Anchordoquy
Jan 15, 2014·International Journal of Pharmaceutics·Nehal IbrahimFrançoise Nepveu
Dec 11, 2003·Molecular Therapy : the Journal of the American Society of Gene Therapy·Alex V SokoloffJon A Wolff
Feb 2, 2019·Current Pharmaceutical Design·Jatinder Kaur Mukker, Ravi Shankar Prasad Singh
Sep 18, 2020·Advances in Colloid and Interface Science·Aoxue ZhangShuyu Xie
Oct 16, 2010·ACS Nano·Mingguang LiJoshua Reineke

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