The biliary route is very important for the elimination of some foreign compounds from the body. For many of these compounds, an increase in the rate at which they are excreted into the bile will decrease their toxicity and vice versa. A number of factors which are known to alter the biliary excretion of xenobiotics, as well as the current concepts of the physiological mechanisms responsible for the excretion of foreign compounds, have been enumerated. However, much remains still to be understood; essentially nothing is known at the subcellular level about the biliary excretion of foreign compounds. It has recently been concluded that our knowledge of the biliary excretion of compounds is about 40 years behind that of the renal excretion mechanism.
Deficiency of hepatic organic anion-binding protein as a possible cause of non-haemolytic unconjugated hyperbilirubinaemia in the newborn
Increased clearance of antipyrine and d-propranolol after phenobarbital treatment in the monkey. Relative contributions of enzyme induction and increased hepatic blood flow
Distribution of quaternary ammonium compounds between particulate and soluble constituents of rat liver, in relation to their transport from plasma into bile
Plasma disappearance and biliary excretion of sulfobromophthalein and phenol-3,6-dibromphthalein disulfonate after microsomal enzyme induction
Effect of phenobarbital on hepatic transport and excretion of 131 I-rose bengal in children with cholestasis
Biliary excretion of phenyl- and methyl mercury chlorides and their enterohepatic circulation in rats
Conversion of metallothionein into Cu-thionein, the possible low molecular weight form of neonatal hepatic mitochondrocuprein
The possible role of cytochrome P-450 in the liver "first pass elimination" of a beta-receptor blocking drug
Binding of cadmium and mercury by metallothionein in the kidneys and liver of rats following repeated administration
Circular dichroism studies of Y protein (ligandin), a major organic anion binding protein in liver, kidney, and small intestine
Primate biliary physiology. 8. The effect of phenobarbital upon bile salt synthesis and pool size, biliary lipid secretion, and bile composition
Development in the newborn rat of the conjugation and de-conjugation processes involved in the enterohepatic circulation of diethylstilboestrol
Species variations in the threshold molecular-weight factor for the biliary excretion of organic anions
The effect of altered hepatic function on the toxicity, plasma disappearance and biliary excretion of diethylstilbestrol
Comparison of the toxicity of chemicals in newborn rats to bile duct-ligated and sham-operated rats and mice
Kinetics of nortiptyline (NT) in rats in vivo and in the isolated perfused liver: demonstration of a 'first pass disappearance' of NT in the liver
Cleavage by beta-glucuronidase of the water-soluble metabolites of digitoxin excreted in the bile of control and spironolactone-pretreated rats
Mercury binding in the kidney and liver of rats repeatedly exposed to mercuric chloride: induction of metallothionein by mercury and cadmium
Concentration of propoxyphene in human plasma following oral, intramuscular, and intravenous administration
Two hepatic cytoplasmic protein fractions, Y and Z, and their possible role in the hepatic uptake of bilirubin, sulfobromophthalein, and other anions
Deficiency of hepatic organic anion-binding protein, impaired organic anion uptake by liver and "physiologic" jaundice in newborn monkeys
Effect of pretreatment with spironolactone, phenobarbital or -diethylaminoethyl diphenylpropylacetate (SKF 525-A) on tritium levels in blood, heart and liver of rats at various times after administration of ( 3 H)digitoxin
Molecular weight and chemical structure as factors in the biliary excretion of sulphonamides in the rat
Studies of Y and Z, two hepatic cytoplasmic organic anion-binding proteins: effect of drugs, chemicals, hormones, and cholestasis
Interruption of the enterohepatic circulation of digitoxin by cholestyramine. I. Protection against lethal digitoxin intoxication
Interruption of the enterohepatic circulation of digitoxin by cholestyramine. II. Effect on metabolic disposition of tritium-labeled digitoxin and cardiac systolic intervals in man
The cardiac glycoside sensitive step in the hepatic transport of the bisquaternary ammonium compound, hexafluorenium
Inhibition of ouabain-H3 uptake by liver slices and its excretion into the bile and by compounds having a steroid nucleus
Temporal aspects of carbon tetrachloride-induced alteration of sulfobromophthalein excretion and metabolism
The role of the hepatic endoplasmic reticulum in the biliary excretion of foreign compounds by the rat. The effect of phenobarbitone and SKF 525-A (diethylaminoethyl diphenylpropylacetate)
Metabolism and biliary excretion of the lipophilic drug molecules, imipramine and desmethylimipramine in the rat. II. Uptake into bile micelles
Effect of phenobarbital and 3-methylcholanthrene pretreatment on guinea pig hepatic microsomal bilirubin glucuronyltransferase activity
Increased thyroxine turnover and thyroidal function after stimulation of hepatocellular binding of thyroxine by phenobarbital
Studies on the relationship between molecular structure and the biliary excretion of organic compounds
Factors determining the maximal rate of organic anion secretion by the liver and further evidence on the hepatic site of action of the hormone secretin
Maximum biliary excretion of bilirubin and sulfobromophthalein during anesthesia-induced alteration of rectal temperature
Hepatic transport of organic cations: active uptake of a quaternary ammonium compound, procaine amide ethobromide. by rat liver slices
DETOXIFICATION IN THE NEWBORN: THE ABILITY OF THE NEWBORN INFANT TO FORM CONJUGATES WITH GLUCURONIC ACID, GLYCINE, ACETATE AND GLUTATHIONE
Biliary excretion of foreign compounds. Biphenyl, stilboestrol and phenolphthalein in the rat: molecular weight, polarity and metabolism as factors in biliary excretion
Plasma disappearance and biliary excretion of bromosulfophthalein in styrene-treated and styrene oxide-treated rats
How we have learned about the complexity of physiology, pathobiology and pharmacology of bile acids and biliary secretion
Techniques for microfloral and associated metabolic studies in relation to the absorption and enterohepatic circulation of drugs
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.
Chronic Fatigue Syndrome
Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.
Systemic Juvenile Idiopathic Arthritis
Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.
Chromatin Regulation and Circadian Clocks
The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.
Central Pontine Myelinolysis
Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.
Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.
Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.
Cell Atlas Along the Gut-Brain Axis
Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.
Chronic Traumatic Encephalopathy
Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.