Biliary excretion of xenobiotics

CRC Critical Reviews in Toxicology
C D Klaassen

Abstract

The biliary route is very important for the elimination of some foreign compounds from the body. For many of these compounds, an increase in the rate at which they are excreted into the bile will decrease their toxicity and vice versa. A number of factors which are known to alter the biliary excretion of xenobiotics, as well as the current concepts of the physiological mechanisms responsible for the excretion of foreign compounds, have been enumerated. However, much remains still to be understood; essentially nothing is known at the subcellular level about the biliary excretion of foreign compounds. It has recently been concluded that our knowledge of the biliary excretion of compounds is about 40 years behind that of the renal excretion mechanism.

References

Apr 15, 1975·Biochemical Pharmacology·C D Klaassen
Nov 1, 1970·Toxicology and Applied Pharmacology·M J AshtonJ T Ritchie
Jan 1, 1971·Naunyn-Schmiedebergs Archiv Für Pharmakologie·G PaumgartnerG Grabner
Oct 1, 1971·The American Journal of Physiology·J L Boyer
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·U AbshagenN Rietbrock
Sep 1, 1974·Toxicology and Applied Pharmacology·C D Klaassen, D W Shoeman
Sep 1, 1974·Toxicology and Applied Pharmacology·C D Klaassen
Sep 1, 1974·Toxicology and Applied Pharmacology·C D Klaassen
Jun 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·T H KentR Marr
Mar 15, 1974·FEBS Letters·H RuppU Weser
Nov 1, 1974·Archives of Biochemistry and Biophysics·M KimuraN Horiuchi
Nov 28, 1973·Nature: New Biology·L Magos, T W Clarkson
Mar 1, 1972·The Journal of Clinical Investigation·G FleischnerI M ARIAS
Jul 1, 1972·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·L J Fischer, J L Weissinger
Dec 1, 1972·Toxicology and Applied Pharmacology·R H Reuning, L S SCHANKER
Oct 15, 1972·Biochemical Pharmacology·M Webb
Oct 15, 1972·Biochemical Pharmacology·M Webb
Jan 1, 1972·Pharmacology·D G ShandG H Evans
Dec 1, 1972·Archives of Biochemistry and Biophysics·D R Winge, K V Rajagopalan
Apr 1, 1973·Archives of Environmental Health·T W ClarksonT Norseth
Jan 1, 1973·Acta Pharmacologica Et Toxicologica·T Norseth
Aug 30, 1973·Archiv Für Toxikologie·M Cikrt
Nov 1, 1973·European Journal of Biochemistry·U WeserG Jung
Oct 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·C D Klaassen
Apr 1, 1974·Canadian Journal of Physiology and Pharmacology·C D Klaassen
Jul 1, 1974·The American Journal of Physiology·J L Barnhart, B Combes
Feb 15, 1974·FEBS Letters·R H Bühler, J H Kägi
Jan 1, 1968·Annual Review of Pharmacology·C M Stowe, G L Plaa
Jun 30, 1971·Nature: New Biology·R I LevineI M ARIAS
Apr 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·A HunterJ Doull
Jun 1, 1972·The Journal of Clinical Investigation·H O Wheeler, K K King
Jul 1, 1972·Journal of Reproduction and Fertility·M Webb
Jun 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·J E Haddow, P Marshall
Feb 1, 1972·The Biochemical Journal·G F NordbergO Vesterberg
May 1, 1972·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P C HiromR T Williams
Jun 1, 1971·The American Journal of Physiology·A Despopoulos
Oct 1, 1971·Biochemical Pharmacology·E E OhnhausA Breckenridge
Sep 15, 1971·Experientia·Z A Shaikh, O J Lucis
Nov 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·C D Klaassen
Dec 1, 1971·The Journal of Clinical Investigation·S H RobinsonS Nagasawa
Sep 1, 1971·British Journal of Pharmacology·C D Klaassen
Dec 15, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·D G ShandA S Nies
Jan 1, 1971·Acta Pharmacologica Et Toxicologica·G F NordbergB Lind
Sep 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·H ReyesI M ARIAS
Dec 1, 1969·The American Journal of Physiology·P K Nayak, L S SCHANKER
Dec 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·P L GigonL S SCHANKER
Jan 1, 1970·Clinical Pharmacology and Therapeutics·D G ShandJ A Oates
Aug 1, 1970·The American Journal of Physiology·S ErlingerM Dumont
Sep 1, 1970·The American Journal of Physiology·P BerthelotA M Preaux
Jan 1, 1970·European Journal of Pharmacology·D K MeijerK J van der Laan
Sep 1, 1970·Life Sciences. Pt. 1: Physiology and Pharmacology·R C Lanman, L S SCHANKER
Nov 1, 1970·Toxicology and Applied Pharmacology·D A BrodieG E Dagle
Nov 1, 1970·Toxicology and Applied Pharmacology·B G Priestly, G L Plaa
Jan 1, 1970·Biochemical Pharmacology·P H GranthamJ H Weisburger
Mar 1, 1971·The American Journal of Physiology·G Whelan, B Combes
May 1, 1971·Archives of Environmental Health·T Norseth, T W Clarkson
Apr 1, 1968·The American Journal of Physiology·H O WheelerS E Bradley
Jan 1, 1968·Toxicology and Applied Pharmacology·C D Klaassen, G L Plaa
Jun 1, 1968·Biochemical Pharmacology·J A Goldstein, A Taurog
Jun 1, 1968·Journal of Pharmaceutical Sciences·B A BeckerJ E Gibson
Sep 1, 1968·The Journal of Physiology·P M Pugh, S L Stone
May 1, 1968·The American Journal of Physiology·H J Kupferberg, L S Schankl
Feb 1, 1969·The Journal of General Physiology·S AlpertI M ARIAS
May 16, 1969·Science·H SelyeL Savoie
Jul 1, 1969·The American Journal of Physiology·L G HartR H Adamson
Sep 1, 1969·Toxicology and Applied Pharmacology·C D Klaassen, G L Plaa
Jul 1, 1966·The American Journal of Physiology·P S PapavasiliouG C Cotzias
Sep 1, 1966·The American Journal of Physiology·L G Hart, L S SCHANKER
May 1, 1966·Biochemistry·P PulidoB L Vallee
Jul 1, 1966·Toxicology and Applied Pharmacology·C D Klaassen, G L Plaa
May 1, 1967·The American Journal of Physiology·A Despopoulos, H Sonnenberg
May 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·R J RobertsG L Plaa
May 1, 1967·Biochemical Pharmacology·R J Roberts, G L Plaa
Nov 1, 1967·The American Journal of Physiology·C D Klaassen, G L Plaa
Nov 1, 1967·Journal of Pharmaceutical Sciences·J E Gibson, B A Becker
Oct 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·E L ForkerH Sornson
Aug 1, 1953·Endocrinology·D J HANAHANH J DAUBEN
Mar 28, 1959·Journal of the American Medical Association·R W BRAUER
Jan 1, 1959·Proceedings of the Society for Experimental Biology and Medicine·P SAMUEL, A STEINER
Apr 1, 1959·Archives of Disease in Childhood·T E OPPE, I E GIBBS
May 1, 1961·The American Journal of Physiology·L S SCHANKER, C A HOGBEN
Sep 1, 1959·The Journal of Pharmacy and Pharmacology·E COXS E WRIGHT
May 1, 1962·The Journal of Clinical Investigation·M F VEST
May 1, 1963·The American Journal of Physiology·L S SCHANKER, H M SOLOMON
Dec 30, 1963·Annals of the New York Academy of Sciences·B H BILLINGM A CARTTER
Jul 1, 1964·The American Journal of Physiology·C A GORESKY
Jul 1, 1964·Clinical Pharmacology and Therapeutics·A K DONE
Apr 1, 1965·The American Journal of Digestive Diseases·W S ROSENTHALG B GLASS
Apr 1, 1965·Biochemical Pharmacology·J M FUJIMOTOH R NICHOLS
Mar 12, 1965·Annals of the New York Academy of Sciences·R T WilliamsR L Smith
Jul 15, 1960·Acta Physiologica Scandinavica·L JUHLIN
May 1, 1961·The American Journal of Physiology·I M ARIASS WOLFSON
Dec 1, 1967·The Biochemical Journal·M M Abou-El-MakaremR T Williams
Dec 1, 1967·The Biochemical Journal·P MillburnR T Williams
Dec 1, 1967·The Biochemical Journal·M M Abou-El-MakaremR T Williams
Mar 1, 1949·Archives of Disease in Childhood·P L MOLLISON, M CUTBUSH
Mar 1, 1949·Archives of Disease in Childhood·S YUDKIN, S S GELLIS
May 4, 1946·Nature·K L BLAXTER, A T COWIE

Citations

Oct 1, 1981·Journal of Toxicology and Environmental Health·S Chakrabarti, J Brodeur
Aug 1, 1987·Bulletin of Environmental Contamination and Toxicology·J Hellou, A King
Sep 1, 1982·Journal of Toxicology and Environmental Health·T C MarshallA L Brooks
Oct 1, 1977·Environmental Health Perspectives·E S Reynolds
May 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M LewittesI M Yousef
Dec 1, 1981·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H P Illing

Related Concepts

Senility
Anthropoidea
Biliary Sludge
Metal Antagonists
Digitalis Glycosides
Canis familiaris
Pharmaceutical Preparations
Enterohepatic Circulation
Enzyme Induction
Cavia porcellus

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.