PMID: 7336127Jan 1, 1981Paper

Biliary lipid composition in obesity

Scandinavian Journal of Gastroenterology
B AngelinB Leijd

Abstract

Fasting gallbladder bile was obtained under standardized conditions from 15 gallstone-free obese subjects (greater than 130% of ideal weight) and 23 healthy control subjects matched for age, sex, and serum lipid levels. The proportion of cholesterol, expressed as molar percentage of total biliary lipids, was increased in obesity (10.8 +/- 0.6 versus 6.8 +/- 0.4 M % (mean +/- S.E.M.), P less than 0.001), whereas that of bile acids was decreased (64.7 +/- 1.3 versus 71.0 +/- 1.0 M %, P less than 0.001). The cholesterol saturation of bile was higher in obesity (141 +/- 7%) than in controls (96 +/- 5%, P less than 0.001). The results provide an explanation of the enhanced frequency of cholesterol gallstones in obese subjects.

References

Jun 1, 1979·European Journal of Clinical Investigation·B AngelinB Leijd
Nov 23, 1978·The New England Journal of Medicine·L J Bennion, S M Grundy
May 1, 1977·The Journal of Clinical Investigation·E A Shaffer, D M Small
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Sep 1, 1980·Clinical Science·B Leijd

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Citations

Jun 1, 1979·Digestive Diseases and Sciences·J AhlbergB Leijd
Oct 1, 1995·European Journal of Clinical Investigation·P PortincasaG Palasciano
Feb 1, 1992·Journal of Internal Medicine·G PalascianoR Giorgino
Mar 4, 2008·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Masae Ohno
Mar 26, 2010·Scandinavian Journal of Gastroenterology·Antal BajorHasse Abrahamsson
Mar 19, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Stephanie Sik Yu SoHani El-Nezami
Feb 1, 1985·The Proceedings of the Nutrition Society·T S Low-Beer
Jan 1, 1988·Digestive Diseases and Sciences·L MarzioF Cuccurullo

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