PMID: 698170Sep 1, 1978Paper

Biliary lipids, bile acids and gallstone formation in hypovitaminotic C guinea-pigs

The British Journal of Nutrition
S A Jenkins

Abstract

1. Hypovitaminotic C guinea-pigs fed on a high-cholesterol diet for 5 weeks developed gallstones (810 mg cholesterol/g) whereas no concretements were observed in vitamin C-replete animals. 2. Scanning electron microscope studies of the three types of gallstone observed in the gallbladders of vitamin C-deficient animals showed them to be composed of randomly-arranged needle-shaped or laminated crystal of cholesterol. 3. The hepatic bile of gallstone-forming animals had a higher cholesterol concentration and lower bile acid content, the latter being principally due to a reduction in the chenodeoxycholic fraction, than the bile of vitamin C-replete animals. 4. No significant difference was observed between the volume of bile secreted by hypovitaminotic C and vitamin C-replete animals, but due to the qualitative changes in bile composition, gallstone formation was associated with an increased biliary secretion of cholesterol and a reduced secretion of bile acids.

References

Aug 8, 1977·Biochemical and Biophysical Research Communications·S A Jenkins
Jul 1, 1976·The British Journal of Nutrition·R M MurrayR A Leng
Dec 6, 1973·The New England Journal of Medicine·H R AlmondL Swell
Nov 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·C D Klaassen
May 1, 1971·The Tohoku Journal of Experimental Medicine·T Ogata, F Murata
May 1, 1968·The Journal of Clinical Investigation·W H Admirand, D M Small
Jan 1, 1965·The British Journal of Nutrition·R A Leng, G J Leonard
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Sep 1, 1960·Clinica Chimica Acta; International Journal of Clinical Chemistry·D WATSON

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Citations

Jan 1, 1992·Critical Reviews in Food Science and Nutrition·H Hemilä
Aug 1, 1997·Gut·P PortincasaG P Vanberge-Henegouwen
Aug 14, 1998·American Journal of Public Health·J A Simon, E S Hudes
Jan 31, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Frank LammertMartin C Carey
Jul 8, 2011·Digestive Diseases·Caroline S StokesFrank Lammert
Jan 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W W LaMorteL F Williams
May 31, 2017·Current Medicinal Chemistry·Agostino Di CiaulaPiero Portincasa
Nov 14, 1986·Biochimica Et Biophysica Acta·N Tavoloni
Sep 8, 2021·Journal of Agricultural and Food Chemistry·Sinah ReiterThomas Hofmann

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